node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHD | CG14184 | FBpp0076545 | FBpp0074641 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | 0.814 |
BHD | CG14812 | FBpp0076545 | FBpp0305695 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | 0.825 |
BHD | CG14977 | FBpp0076545 | FBpp0303128 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. | 0.808 |
BHD | CG3764 | FBpp0076545 | FBpp0302831 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | RE13835p; ATPase inhibitor activity; chaperone binding. It is involved in the biological process described with: negative regulation of TORC1 signaling. | 0.989 |
BHD | CG5110 | FBpp0076545 | FBpp0297292 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family. | 0.830 |
BHD | CG5189 | FBpp0076545 | FBpp0289083 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Belongs to the GAMAD family. | 0.814 |
BHD | Cpr73D | FBpp0076545 | FBpp0112089 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | Cuticular protein 73D, isoform B; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development. | 0.901 |
BHD | Nprl2 | FBpp0076545 | FBpp0074122 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | GATOR complex protein NPRL2; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...] | 0.788 |
BHD | RagA-B | FBpp0076545 | FBpp0081491 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | Ras-related GTP binding A/B (RagA-B) encodes a Ras family GTPase that forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of Tor by recruiting it to the lysosome. | 0.998 |
BHD | RagC-D | FBpp0076545 | FBpp0087883 | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | Protein heterodimerization activity; GTP binding; GTPase activity. It is involved in the biological process described with: regulation of autophagy; positive regulation of TOR signaling; cellular response to starvation; positive regulation of TORC1 signaling; cellular response to amino acid stimulus. | 0.997 |
CG14184 | BHD | FBpp0074641 | FBpp0076545 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Birt-Hogg-Dube (BHD) encodes a protein involved in the maintenance of germ-line stem cells and the regulation of nucleolar large rRNA transcription. | 0.814 |
CG14184 | CG14812 | FBpp0074641 | FBpp0305695 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. | 0.999 |
CG14184 | CG14977 | FBpp0074641 | FBpp0303128 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. | 0.999 |
CG14184 | CG3764 | FBpp0074641 | FBpp0302831 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | RE13835p; ATPase inhibitor activity; chaperone binding. It is involved in the biological process described with: negative regulation of TORC1 signaling. | 0.671 |
CG14184 | CG5110 | FBpp0074641 | FBpp0297292 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family. | 0.999 |
CG14184 | CG5189 | FBpp0074641 | FBpp0289083 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Belongs to the GAMAD family. | 0.999 |
CG14184 | Cpr73D | FBpp0074641 | FBpp0112089 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Cuticular protein 73D, isoform B; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development. | 0.475 |
CG14184 | Nprl2 | FBpp0074641 | FBpp0074122 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | GATOR complex protein NPRL2; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid o [...] | 0.629 |
CG14184 | RagA-B | FBpp0074641 | FBpp0081491 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Ras-related GTP binding A/B (RagA-B) encodes a Ras family GTPase that forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of Tor by recruiting it to the lysosome. | 0.994 |
CG14184 | RagC-D | FBpp0074641 | FBpp0087883 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. | Protein heterodimerization activity; GTP binding; GTPase activity. It is involved in the biological process described with: regulation of autophagy; positive regulation of TOR signaling; cellular response to starvation; positive regulation of TORC1 signaling; cellular response to amino acid stimulus. | 0.995 |