STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ecoN-acetyltransferase eco; Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. (1052 aa)    
Predicted Functional Partners:
SMC3
Structural maintenance of chromosomes 3 (SMC3) encodes a subunit of the cohesin complex. It is involved in planar cell polarity by regulating the membrane enrichment of the transmembrane cadherin encoded by stan.
   
 0.983
pds5
Precocious dissociation of sisters 5 (pds5) encodes a protein that interacts with the product of wapl to form the releasin complex, which enables sister chromatid separation at mitosis by removing the cohesin ring complex from chromosomes. The product of pds5 influences gene activation and silencing through interactions with cohesin. It is also required to initiate and/or maintain sister chromatid cohesion.
   
 0.940
vtd
Rad21 mitotic cohesin; Verthandi (vtd) encodes a subunit of the cohesin complex, which encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair.
   
 0.933
SMC1
Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair.
   
 0.919
glu
Structural maintenance of chromosomes protein; Gluon (glu) encodes a subunit of the multiprotein complex condensin that is required for chromosome condensation and sister chromatid segregation. It contributes to nervous system development and glucose metabolism.
   
 
 0.898
SMC2
Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation.
   
 
 0.889
SMC5
Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes.
   
 
 0.867
D1
D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II.
   
 
 0.861
Gcn5
Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis.
      
 0.859
jnj
Java no jive (jnj) encodes the Smc6 subunit of the SMC5/6 protein complex. It is involved genotoxic stress and response to caffeine.
   
 
 0.837
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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