| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| D1 | SMC1 | FBpp0081467 | FBpp0083926 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | 0.953 |
| D1 | SMC2 | FBpp0081467 | FBpp0086591 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation. | 0.627 |
| D1 | SMC3 | FBpp0081467 | FBpp0074065 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | Structural maintenance of chromosomes 3 (SMC3) encodes a subunit of the cohesin complex. It is involved in planar cell polarity by regulating the membrane enrichment of the transmembrane cadherin encoded by stan. | 0.943 |
| D1 | SMC5 | FBpp0081467 | FBpp0290815 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes. | 0.744 |
| D1 | eco | FBpp0081467 | FBpp0076592 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | N-acetyltransferase eco; Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. | 0.861 |
| D1 | glu | FBpp0081467 | FBpp0080489 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | Structural maintenance of chromosomes protein; Gluon (glu) encodes a subunit of the multiprotein complex condensin that is required for chromosome condensation and sister chromatid segregation. It contributes to nervous system development and glucose metabolism. | 0.727 |
| D1 | jnj | FBpp0081467 | FBpp0083958 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | Java no jive (jnj) encodes the Smc6 subunit of the SMC5/6 protein complex. It is involved genotoxic stress and response to caffeine. | 0.667 |
| D1 | vtd | FBpp0081467 | FBpp0112469 | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | Rad21 mitotic cohesin; Verthandi (vtd) encodes a subunit of the cohesin complex, which encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | 0.837 |
| Gcn5 | eco | FBpp0075701 | FBpp0076592 | Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. | N-acetyltransferase eco; Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. | 0.859 |
| SMC1 | D1 | FBpp0083926 | FBpp0081467 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | 0.953 |
| SMC1 | SMC2 | FBpp0083926 | FBpp0086591 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation. | 0.744 |
| SMC1 | SMC3 | FBpp0083926 | FBpp0074065 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | Structural maintenance of chromosomes 3 (SMC3) encodes a subunit of the cohesin complex. It is involved in planar cell polarity by regulating the membrane enrichment of the transmembrane cadherin encoded by stan. | 0.999 |
| SMC1 | SMC5 | FBpp0083926 | FBpp0290815 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes. | 0.591 |
| SMC1 | eco | FBpp0083926 | FBpp0076592 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | N-acetyltransferase eco; Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. | 0.919 |
| SMC1 | glu | FBpp0083926 | FBpp0080489 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | Structural maintenance of chromosomes protein; Gluon (glu) encodes a subunit of the multiprotein complex condensin that is required for chromosome condensation and sister chromatid segregation. It contributes to nervous system development and glucose metabolism. | 0.805 |
| SMC1 | jnj | FBpp0083926 | FBpp0083958 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | Java no jive (jnj) encodes the Smc6 subunit of the SMC5/6 protein complex. It is involved genotoxic stress and response to caffeine. | 0.604 |
| SMC1 | pds5 | FBpp0083926 | FBpp0297204 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | Precocious dissociation of sisters 5 (pds5) encodes a protein that interacts with the product of wapl to form the releasin complex, which enables sister chromatid separation at mitosis by removing the cohesin ring complex from chromosomes. The product of pds5 influences gene activation and silencing through interactions with cohesin. It is also required to initiate and/or maintain sister chromatid cohesion. | 0.995 |
| SMC1 | vtd | FBpp0083926 | FBpp0112469 | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | Rad21 mitotic cohesin; Verthandi (vtd) encodes a subunit of the cohesin complex, which encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | 0.999 |
| SMC2 | D1 | FBpp0086591 | FBpp0081467 | Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation. | D1 chromosomal protein (D1) encodes a multi-AT-hook chromosomal protein that associates with AT-rich satellites, including the SAT-III repeats of the X-chromosome. The product of D1 binds to the minor-groove of the DNA and favors heterochromatin-mediated gene repression involving its interaction with topoisomerase II. | 0.627 |
| SMC2 | SMC1 | FBpp0086591 | FBpp0083926 | Structural maintenance of chromosomes 2 (SMC2) encodes a condensin subunit involved in chromosome condensation and cell division. It contributes to neurogenesis and stem cell differentiation. | Structural maintenance of chromosomes 1 (SMC1) encodes an ATPase that heterodimerizes with the product of SMC3 to interact with the products of vtd and SA to form the cohesin ring complex. Cohesin encircles sister chromatids after DNA replication and has multiple roles in the regulation of gene expression and DNA repair. | 0.744 |