STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ndlSerine protease nudel; Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Nudel, pipe and windbeutel together trigger the protease cascade within the extraembryonic perivitelline compartment which induces dorsoventral polarity of the Drosophila embryo. Belongs to the peptidase S1 family. (2616 aa)    
Predicted Functional Partners:
psd
Palisade, isoform A; Palisade (psd) encodes a secreted protein required during oogenesis to coordinate assembly and cross-linking of the vitelline membrane layer of the eggshell. It is also one of several targets of the sulfotransferase encoded by pip, which is involved in developmental patterning.
   
   0.764
Vm26Ab
Vitelline membrane protein Vm26Ab; Major early eggshell protein.
   
  
 0.698
dec-1
Defective chorion-1 protein, FC177 isoform; Required for proper assembly of the eggshell.
   
  
 0.679
Cp7Fb
Chorion protein b at 7F (Cp7Fb) belongs to a family of nine Chorion protein genes clustered in two chromosomes (X and 3rd). It is expressed in the follicle cells in a dynamic pattern.
   
  
 0.551
CG12398
GMC_OxRdtase_N domain-containing protein; Oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: oxidation-reduction process; ecdysteroid metabolic process.
   
  
 0.537
Vm32E
Vitelline membrane 32E (Vm32E) encodes a structural component of the vitelline membrane and the endochorion layer.
   
  
 0.532
CG14309
Uncharacterized protein.
   
  
 0.527
CG14834
AT11423p.
   
  
 0.521
Cp7Fa
Chorion protein a at 7F; It is involved in the biological process described with: chorion-containing eggshell formation.
   
  
 0.511
Vm26Aa
Vitelline membrane protein Vm26Aa; Major early eggshell protein; Belongs to the vitelline membrane protein family.
   
    0.509
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]