STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Mdr65Multidrug resistance protein homolog 65; Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1302 aa)    
Predicted Functional Partners:
nrv2
Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
    
 0.936
Atpalpha
Sodium/potassium-transporting ATPase subunit alpha; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
   
 0.915
nrv1
Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
    
  0.901
moody
G-protein coupled receptor moody; Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug- related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in tu [...]
      
 0.791
Mdr50
Multi drug resistance 50; Efflux transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding. It is involved in the biological process described with: response to insecticide; response to toxic substance; xenobiotic transport; transmembrane transport; renal tubular secretion.
  
  
0.759
Mdr49
Multidrug resistance protein homolog 49; Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance.
  
  
0.748
CG10226
Uncharacterized protein, isoform A; Efflux transmembrane transporter activity; ATP binding; ATPase-coupled transmembrane transporter activity; ATPase activity; ATPase-coupled xenobiotic transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; renal tubular secretion; response to toxic substance; xenobiotic transport.
  
 
0.739
Lcp1
Larval cuticle protein 1; Component of the larval cuticle.
      
 0.663
CG31121
FI03229p; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: transmembrane transport.
  
 0.661
CG11069
LD11139p; ATPase-coupled transmembrane transporter activity; ATP binding; ATPase activity. It is involved in the biological process described with: transmembrane transport.
  
0.646
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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