STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ppat-DpckBifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (Ppat-Dpck) encodes a bifunctional enzyme that carries out the last two steps of the canonical Coenzyme A (CoA) biosynthesis pathway. The Ppat part converts 4'-phosphopantetheine into dephospho-CoA and subsequently the Dpck part phosphorylates dephospho-CoA to form CoA. (518 aa)    
Predicted Functional Partners:
fbl
Fumble, isoform E; Fumble (fbl) encodes an enzyme that phosphorylates pantothenate (vitamin B5), which is one of the early steps of the Coenzyme A de novo biosynthesis pathway.
   
 
 0.991
Ppcdc
Phosphopantothenoylcysteine decarboxylase activity. It is involved in the biological process described with: coenzyme A biosynthetic process.
     
 0.990
CG5828
Uncharacterized protein, isoform A; Pantothenate kinase activity. It is involved in the biological process described with: coenzyme A biosynthetic process.
   
 
 0.979
Ppcs
Phosphopantothenoylcysteine synthetase, isoform C; Phosphopantothenate--cysteine ligase activity.
      
 0.913
CG32099
GH12334p; Holo-[acyl-carrier-protein] synthase activity; magnesium ion binding. It is involved in the biological process described with: lysine biosynthetic process via aminoadipic acid.
   
 
  0.900
Mondo
Mlx interactor alpha; Mondo (Mondo) encodes a basic helix-loop-helix-leucine zipper transcription factor involved in lipid and carbohydrate metabolism. Together with its binding partner encoded by bigmax, it controls sugar-dependent gene expression, including activation of genes involved in lipogenesis. Mondo mutants are intolerant to dietary sugars and have impaired muscle function.
    
 
 0.757
bigmax
GM14426p; Bigmax (bigmax) encodes a basic helix-loop-helix-leucine zipper transcription factor. Together with its binding partner encoded by Mondo, the product of bigmax is involved in sugar-dependent gene regulation. It is involved in transcriptional control of many metabolic pathways, including glycolysis, de novo lipogenesis and the pentose phosphate pathway. Loss of bigmax function produces dietary sugar intolerance.
 
 
    0.682
CG1673
Branched-chain-amino-acid transaminase activity. It is involved in the biological process described with: valine biosynthetic process; branched-chain amino acid biosynthetic process; leucine biosynthetic process; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
      
 0.625
Dpck
dephospho-CoA kinase activity; ATP binding. It is involved in the biological process described with: coenzyme A biosynthetic process.
  
 
 
0.533
Urod
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
   
  
 0.507
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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