STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Pp4-19CSerine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes. The probable PP4 complex Pp4- 19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase- induced cell death (in vitro). (307 aa)    
Predicted Functional Partners:
PPP4R2r
Serine/threonine-protein phosphatase 4 regulatory subunit 2; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) (By similarity). The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro).
   
 0.999
Tap42
Two A-associated protein of 42kDa (Tap42) encodes a phosphatase inhibitor involved in wing disc morphogenesis and the organization of the mitotic spindle.
    
 0.997
flfl
Serine/threonine-protein phosphatase 4 regulatory subunit 3; Regulatory subunit of serine/threonine-protein phosphatase 4. The probable PP4 complex Pp4-19C-PPP4R2r-flfl (PPP4C-PPP4R2-PPP4R3) is required to prevent caspase induced cell death (in vitro). May be involved in DNA damage repair. Key mediator specific for the localization of mira and associated cell fate determinants during both interphase and mitosis. Nuclear Flfl is required to exclude mira/pros from the nucleus when inefficiently bound to the cytoskeleton/cortex, whereas cytosolic or membrane-associated flfl is required fo [...]
   
 0.997
Pp2A-29B
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; Protein phosphatase 2A at 29B (Pp2A-29B) encodes the structural A subunit of the trimeric PP2A phosphatase enzyme. It links the catalytic C subunit encoded by mts and a variable regulatory B family subunit, which directs the enzyme to distinct substrates. The roles of Pp2A-29B product include centriole duplication, chromosome segregation, autophagy, axonal transport, growth regulation, and active zone stabilization.
   
 0.973
Ptpa
Phosphotyrosyl phosphatase activator (Ptpa) encodes a nuclear protein that associates with the catalytic subunit of the PP4 complex encoded by Pp4-19C in larval brain neuroblasts. It facilitates the dephosphorylation and basal distribution of the mira protein during neuroblast asymmetric division.
    
 0.936
tws
Protein phosphatase PP2A 55 kDa regulatory subunit; Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment.
   
 0.926
mts
Serine/threonine-protein phosphatase PP2A; Microtubule star (mts) encodes the catalytic subunit of protein phosphatase 2A. It is involved in various developmental processes and signaling pathways, such as Hh signaling and Wingless signaling; Belongs to the PPP phosphatase family. PP-2A subfamily.
  
0.914
CG2104
Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
    
 0.897
CG8509
Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
    
 0.894
polo
Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
   
 
 0.887
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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