node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amph | Drp1 | FBpp0086941 | FBpp0307166 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.878 |
Amph | Marf | FBpp0086941 | FBpp0310030 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. | 0.623 |
Amph | aux | FBpp0086941 | FBpp0078604 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death. | 0.734 |
Amph | fzo | FBpp0086941 | FBpp0083791 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Transmembrane GTPase fzo; Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. | 0.554 |
Buffy | Debcl | FBpp0087182 | FBpp0085443 | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | 0.972 |
Buffy | Drp1 | FBpp0087182 | FBpp0307166 | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.929 |
Buffy | Marf | FBpp0087182 | FBpp0310030 | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. | 0.438 |
Buffy | Pink1 | FBpp0087182 | FBpp0099833 | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.487 |
Buffy | fzo | FBpp0087182 | FBpp0083791 | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. | Transmembrane GTPase fzo; Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. | 0.438 |
Debcl | Buffy | FBpp0085443 | FBpp0087182 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. | 0.972 |
Debcl | Drp1 | FBpp0085443 | FBpp0307166 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.940 |
Debcl | Fis1 | FBpp0085443 | FBpp0271716 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Functions downstream of Pink1 and upstream of Drp1 to regulate mitochondrial fission. | 0.793 |
Debcl | Marf | FBpp0085443 | FBpp0310030 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. | 0.781 |
Debcl | Pink1 | FBpp0085443 | FBpp0099833 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. | 0.818 |
Debcl | Tango11 | FBpp0085443 | FBpp0071661 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | Transport and Golgi organization protein 11; May play a role in mitochondrial and peroxisomal fission. Belongs to the Tango11 family. | 0.469 |
Debcl | fzo | FBpp0085443 | FBpp0083791 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | Transmembrane GTPase fzo; Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. | 0.705 |
Debcl | park | FBpp0085443 | FBpp0077974 | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. | 0.712 |
Drp1 | Amph | FBpp0307166 | FBpp0086941 | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | 0.878 |
Drp1 | Buffy | FBpp0307166 | FBpp0087182 | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae. | 0.929 |
Drp1 | Debcl | FBpp0307166 | FBpp0085443 | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | 0.940 |