node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG41099 | Gdi | FBpp0112713 | FBpp0311558 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | 0.428 |
CG41099 | Pi3K59F | FBpp0112713 | FBpp0071973 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | 0.470 |
CG41099 | Rab5 | FBpp0112713 | FBpp0077473 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | 0.938 |
CG41099 | Rabex-5 | FBpp0112713 | FBpp0072557 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | Rabaptin-5-associated exchange factor for Rab5; DNA binding; zinc ion binding; Rab guanyl-nucleotide exchange factor activity. | 0.670 |
CG41099 | Rbpn-5 | FBpp0112713 | FBpp0071563 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | Rabaptin-5 (Rbpn-5) encodes a Rab GTPase binding protein involved in regulation of endosome size. | 0.669 |
CG41099 | Rbsn-5 | FBpp0112713 | FBpp0079203 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | Rabenosyn-5 (Rbsn-5) encodes a Rab5-binding effector that controls entry of endocytosed cargo into the early endosome. | 0.858 |
CG41099 | Vps8 | FBpp0112713 | FBpp0076695 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. | 0.421 |
Ccz1 | Gdi | FBpp0073036 | FBpp0311558 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | 0.789 |
Ccz1 | Lamp1 | FBpp0073036 | FBpp0085251 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. | 0.554 |
Ccz1 | Mon1 | FBpp0073036 | FBpp0077079 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Monensin sensitivity 1 (Mon1) encodes a protein that forms a complex with the product of Ccz1 and acts as an exchange factor of the small G-protein encoded by Rab7. It activates and recruits the product of Rab7 to the maturing endosome, inducing the fusion of the matured endosome with the lysosome. Mon1/Ccz1 complex loss of function results in Rab7 phenotypes. | 0.999 |
Ccz1 | Pi3K59F | FBpp0073036 | FBpp0071973 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | 0.750 |
Ccz1 | Rab5 | FBpp0073036 | FBpp0077473 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | 0.938 |
Ccz1 | Rabex-5 | FBpp0073036 | FBpp0072557 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Rabaptin-5-associated exchange factor for Rab5; DNA binding; zinc ion binding; Rab guanyl-nucleotide exchange factor activity. | 0.835 |
Ccz1 | Rbpn-5 | FBpp0073036 | FBpp0071563 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Rabaptin-5 (Rbpn-5) encodes a Rab GTPase binding protein involved in regulation of endosome size. | 0.509 |
Ccz1 | Rbsn-5 | FBpp0073036 | FBpp0079203 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Rabenosyn-5 (Rbsn-5) encodes a Rab5-binding effector that controls entry of endocytosed cargo into the early endosome. | 0.574 |
Ccz1 | Vps8 | FBpp0073036 | FBpp0076695 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. | 0.825 |
Gdi | CG41099 | FBpp0311558 | FBpp0112713 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. | 0.428 |
Gdi | Ccz1 | FBpp0311558 | FBpp0073036 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | 0.789 |
Gdi | Mon1 | FBpp0311558 | FBpp0077079 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Monensin sensitivity 1 (Mon1) encodes a protein that forms a complex with the product of Ccz1 and acts as an exchange factor of the small G-protein encoded by Rab7. It activates and recruits the product of Rab7 to the maturing endosome, inducing the fusion of the matured endosome with the lysosome. Mon1/Ccz1 complex loss of function results in Rab7 phenotypes. | 0.773 |
Gdi | Rab5 | FBpp0311558 | FBpp0077473 | Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. | Rab5, isoform A; Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. | 0.982 |