STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG3662LD27268p; Amyloid-beta binding. It is involved in the biological process described with: multicellular organism reproduction; negative regulation of amyloid precursor protein biosynthetic process. (319 aa)    
Predicted Functional Partners:
sut2
Sugar transporter 2; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
    
 
 0.839
CG2076
RH72958p; Belongs to the BI1 family.
      
 0.762
Mics1
Mitochondrial morphology and cristae structure 1.
      
 0.717
Tsp39D
Tetraspanin.
   
 
 0.672
mt:CoIII
Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]
      
 0.616
Vamp7
Vesicle-associated membrane protein 7 (Vamp7) encodes an R type SNARE protein. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Syx17 and Snap29. It localizes to endosomes in a Rab21 and Sbf dependent manner; Belongs to the synaptobrevin family.
      
 0.578
CG5390
FI06461p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
   
 
 0.564
mt:ND1
NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
      
 0.548
l(1)G0007
Lethal (1) G0007 (l(1)G0007) encodes a protein involved in alternative mRNA splicing regulation.
   
 
 0.532
Cyp4c3
Cytochrome P450 4c3; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
      
 0.522
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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