node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B-H1 | al | FBpp0074204 | FBpp0077713 | Homeobox protein B-H1; B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5. Belongs to the Antp homeobox family. | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | 0.530 |
B-H1 | hth | FBpp0074204 | FBpp0081732 | Homeobox protein B-H1; B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5. Belongs to the Antp homeobox family. | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] | 0.544 |
C15 | al | FBpp0083510 | FBpp0077713 | FI01111p; C15 (C15) encodes a transcription factor that regulates gene expression in the leg distal region. | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | 0.978 |
Lim1 | Optix | FBpp0071216 | FBpp0302920 | LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. | Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. | 0.610 |
Lim1 | al | FBpp0071216 | FBpp0077713 | LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | 0.618 |
Lim1 | hth | FBpp0071216 | FBpp0081732 | LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] | 0.582 |
Optix | Lim1 | FBpp0302920 | FBpp0071216 | Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. | LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. | 0.610 |
Optix | al | FBpp0302920 | FBpp0077713 | Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | 0.624 |
Optix | hth | FBpp0302920 | FBpp0081732 | Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] | 0.719 |
Optix | salr | FBpp0302920 | FBpp0297936 | Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. | Spalt-related, isoform A; Spalt-related (salr) encodes a zinc finger transcriptional repressor that, together with the product of salm, mediates most dpp functions during development of the central part of the wing. It is repressed by the product of Ubx during haltere development. | 0.538 |
Optix | wg | FBpp0302920 | FBpp0079060 | Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] | 0.549 |
Ubx | al | FBpp0082793 | FBpp0077713 | Homeotic protein ultrabithorax; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor; Belongs to the Antp homeobox family. | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | 0.625 |
Ubx | hth | FBpp0082793 | FBpp0081732 | Homeotic protein ultrabithorax; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor; Belongs to the Antp homeobox family. | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] | 0.767 |
al | B-H1 | FBpp0077713 | FBpp0074204 | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | Homeobox protein B-H1; B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5. Belongs to the Antp homeobox family. | 0.530 |
al | C15 | FBpp0077713 | FBpp0083510 | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | FI01111p; C15 (C15) encodes a transcription factor that regulates gene expression in the leg distal region. | 0.978 |
al | Lim1 | FBpp0077713 | FBpp0071216 | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | LIM homeobox 1 (Lim1) encodes a transcription factor protein involved in eye development and leg morphogenesis. | 0.618 |
al | Optix | FBpp0077713 | FBpp0302920 | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement. | 0.624 |
al | Ubx | FBpp0077713 | FBpp0082793 | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | Homeotic protein ultrabithorax; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor; Belongs to the Antp homeobox family. | 0.625 |
al | hth | FBpp0077713 | FBpp0081732 | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] | 0.516 |
al | salr | FBpp0077713 | FBpp0297936 | Homeobox protein aristaless; Involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages. Also has a role in early imaginal disk development; Belongs to the paired homeobox family. | Spalt-related, isoform A; Spalt-related (salr) encodes a zinc finger transcriptional repressor that, together with the product of salm, mediates most dpp functions during development of the central part of the wing. It is repressed by the product of Ubx during haltere development. | 0.681 |