STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PitslreSerine/threonine-protein kinase PITSLRE; Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity). (952 aa)    
Predicted Functional Partners:
CG16903
LD24704p; Cyclin-dependent protein serine/threonine kinase regulator activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
 
 0.559
cdc14
Cell division cycle 14, isoform A; Protein tyrosine/serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity.
      
 0.494
east
Enhanced adult sensory threshold (east) encodes a ubiquitous protein localized to an extrachromosomal domain of the nucleus. It is involved in chemosensory behavior, chromosome segregation during cell division, cell survival and muscle development.
   
  
 0.454
CG15390
RE18748p; Double-stranded DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; mitochondrial transcription; mitochondrial ribosome assembly.
      
 0.422
Sin
Sex-lethal interactor, isoform A; Protein binding; DNA-directed 5'-3' RNA polymerase activity. It is involved in the biological process described with: transcription, DNA-templated.
      
 0.420
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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