STRINGSTRING
dgrn protein (fruit fly) - STRING interaction network
"dgrn" - Degringolade, isoform A in Drosophila melanogaster
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dgrnDegringolade, isoform A; Degringolade is a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics (319 aa)    
Predicted Functional Partners:
Tm1
Tropomyosin-1, isoforms 9A/A/B; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction; Belongs to the tropomyosin family (711 aa)
     
      0.989
CG10681
annotation not available (212 aa)
     
      0.989
CG7357
LD33778p; DNA binding; zinc ion binding (430 aa)
     
      0.989
CG7824
annotation not available (352 aa)
     
      0.989
CG8851
CG8851, isoform C; It is involved in the biological process described with- neurogenesis (723 aa)
       
      0.989
CG13477
annotation not available (113 aa)
       
      0.989
smt3
Small ubiquitin-related modifier; Smt3 is the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis (90 aa)
     
 
  0.968
CG4449
annotation not available (424 aa)
     
 
  0.960
lwr
Lesswright encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo (159 aa)
       
 
  0.904
Hel89B
Helicase 89B, isoform B; ATP binding; DNA binding; ATP-dependent DNA helicase activity; helicase activity. It is involved in the biological process described with- innate immune response; Toll signaling pathway; positive regulation of antibacterial peptide biosynthetic process; antimicrobial humoral response; defense response to bacterium (1923 aa)
     
   
  0.816
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: low (8%) [ZH]