STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rab23RH23273p; Rab23 (Rab23) encodes a member of the Rab family of small GTPases known to be involved in vesicle transport processes. It cooperates with the product of in and the core group of planar cell polarity genes. It contributes to restricting actin accumulation and thus, prehair initiation to a single site within each wing cell, and to regulate the number and orientation of hairs on the leg and the abdominal cuticle. In addition, it regulates the trafficking of the ligand encoded by hh in the germline stem cell niche. (268 aa)    
Predicted Functional Partners:
smo
Protein smoothened; Segment polarity protein required for correct patterning of every segment. G protein-coupled receptor that associates with the patched protein (ptc) to transduce the hedgehog (hh) signal through the activation of an inhibitory G-protein. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which a [...]
   
  
 0.810
dnd
Dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process.
    
 
 0.759
Su(fu)
Suppressor of fused (Su(fu)) encodes a negative regulator of the Hedgehog signaling pathway. It forms a complex with the transcription factor encoded by ci to inhibit its activity; Belongs to the SUFU family.
   
  
 0.738
in
Inturned (in) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway, which controls hair and bristle polarity in the adult. In directly binds with the products of fy, frtz and mwh and accumulates on the proximal side of wing cells.
    
 
 0.685
RabX6
RabX6, isoform B; GTPase activity; GTP binding. It is involved in the biological process described with: intracellular protein transport; Rab protein signal transduction; vesicle-mediated transport.
  
0.623
Rep
Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity).
   
 
 0.611
RabX5
RabX5; GTP binding; GTPase activity. It is involved in the biological process described with: vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport.
  
  
0.605
Gdi
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
    
 
 0.600
frtz
Fritz (frtz) encodes a cytoplasmic protein that functions as a planar polarity effector as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity. frtz protein directly binds to the product of in and accumulates on the proximal side of wing cells.
    
 
 0.591
Rab40
Rab40, isoform B; GTP binding; GTPase activity. It is involved in the biological process described with: protein localization to plasma membrane; vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport.
   
 
0.589
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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