STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG14646RE35255p; Ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination. (409 aa)    
Predicted Functional Partners:
CG13605
LP20373p; Ubiquitin protein ligase activity; zinc ion binding.
   
 
 0.674
Pex6
Peroxin 6, isoform D; ATP binding; ATPase activity. It is involved in the biological process described with: peroxisome organization; protein import into peroxisome matrix; protein targeting to peroxisome.
   
   0.639
Hrd3
HMG-coA reductase degradation 3, isoform A; It is involved in the biological process described with: ubiquitin-dependent ERAD pathway.
   
 
 0.447
Der-1
Derlin-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
   
 
 0.435
CG33144
Ubiquitin-protein transferase activity; zinc ion binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process.
   
  
 0.408
CG8237
LD27256p.
   
  
 0.403
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (30%) [HD]