STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pgant5Polypeptide N-acetylgalactosaminyltransferase 5; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers EA2 as substrate. In the larval midgut, required for O- glycosylation of apical and luminal proteins within copper cell [...] (630 aa)    
Predicted Functional Partners:
O-fut2
GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of a number of protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families.
      
 0.835
C1GalTA
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Core 1 Galactosyltransferase A (C1GalTA) encodes a protein that exhibits strong core 1beta1,3GalT activity, and is involved in the synthesis of T antigen in hemocytes. Its roles include hematopoietic stem cell maintenance, neural network and neuromuscular junction formation.
   
 
 0.739
Rab6
Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...]
   
 
  0.731
Pgant7
N-acetylgalactosaminyltransferase 7; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D- galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide s [...]
  
0.710
CG3792
Mannose-P-dolichol utilization defect 1 protein homolog; It is involved in the biological process described with: protein glycosylation; oligosaccharide biosynthetic process.
      
 0.698
Pmi
Transmembrane protein 11 homolog, mitochondrial; Pmi (Pmi) encodes a ubiquitous protein of the mitochondrial inner membrane that negatively controls the biogenesis of cristae membrane. Pmi-dependent cristae alterations are associated with impaired oxidative metabolism, abnormal mitochondrial shape/size, defective mitochondrial transport in neurons, and lead to stress-induced paralysis in adult flies.
      
 0.698
CG2975
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity; beta-1,3-galactosyltransferase activity. It is involved in the biological process described with: multicellular organism reproduction; protein glycosylation; O-glycan processing, core 1.
     
 0.656
CG3119
IP15602p; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. It is involved in the biological process described with: O-glycan processing, core 1.
     
 0.656
CG34056
IP12857p; Beta-1,3-galactosyltransferase activity; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. It is involved in the biological process described with: protein glycosylation; O-glycan processing, core 1.
     
 0.656
CG34057
Uncharacterized protein, isoform A; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. It is involved in the biological process described with: O-glycan processing, core 1.
     
 0.656
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: high (86%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.