STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mmyMummy, isoform A; Mummy (mmy) encodes an UDP-N-acetylglucosamine diphosphorylase. It functions in apical extracellular matrix formation by producing GlcNAc residues needed for chitin synthesis and protein glycosylation. It regulates cuticle production, tracheal morphogenesis, and axon guidance. (520 aa)    
Predicted Functional Partners:
nst
Nesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling.
  
 0.995
kkv
Krotzkopf verkehrt (kkv) encodes a membrane-inserted glycosyltransferase family 2 chitin synthase that uses GlcNAc to produce the polysaccharide chitin, which is extruded to the differentiating cuticle and tracheal system (tracheal cuticle, tube diameter regulation and gas filling).
   
 
 0.982
Chs2
Chitin synthase activity. It is involved in the biological process described with: cuticle chitin biosynthetic process.
   
 0.973
Gfat1
Glutamine:fructose-6-phosphate aminotransferase 1, isoform A; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: carbohydrate derivative biosynthetic process.
   
 
 0.837
Gnpnat
Monosaccharide binding; N-acetyltransferase activity; glucosamine 6-phosphate N-acetyltransferase activity. It is involved in the biological process described with: UDP-N-acetylglucosamine biosynthetic process; Belongs to the acetyltransferase family. GNA1 subfamily.
   
 
 0.797
Galt
Galactose-1-phosphate uridylyltransferase (Galt) encodes an enzyme that contributes to galactose homeostasis and adult locomotory behavior.
    
 
 0.752
Gfat2
Glutamine:fructose-6-phosphate aminotransferase 2; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; protein N-linked glycosylation.
   
 
 0.728
MFS16
Major facilitator superfamily transporter 16, isoform B; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
    
 
 0.706
CG6569
RE30121p.
    
   0.703
Oga
O-GlcNAcase (Oga) encodes a protein that, together with the product of sxc, is responsible for O-GlcNAcylation. O-GlcNAcylation is a dynamic post-translational modification that modifies serine and threonine residues of proteins, and plays important roles in biological functions such as metabolism and neurodegeneration.
      
 0.701
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.