STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
GaltGalactose-1-phosphate uridylyltransferase (Galt) encodes an enzyme that contributes to galactose homeostasis and adult locomotory behavior. (350 aa)    
Predicted Functional Partners:
Gale
UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP- Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconvers [...]
  
 0.999
Galk
Galactokinase, isoform A; Galactokinase (Galk) encodes a protein involved in galactose metabolism that regulates calcineurin-induced cardiac enlargement.
 
 0.999
UGP
UTP--glucose-1-phosphate uridylyltransferase; UGP (UGP) encodes an enzyme involved in hyperoxia response.
   
 0.998
sgl
UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
    
 0.879
Ugalt
UDP-galactose transporter, isoform B; UDP-galactose transporter (Ugalt) encodes a transporter involved in UDP-N-acetylgalactosamine, UDP-galactose and galactose transmembrane transport.
   
  
 0.842
mmy
Mummy, isoform A; Mummy (mmy) encodes an UDP-N-acetylglucosamine diphosphorylase. It functions in apical extracellular matrix formation by producing GlcNAc residues needed for chitin synthesis and protein glycosylation. It regulates cuticle production, tracheal morphogenesis, and axon guidance.
    
 
 0.752
Uxs
UDP-xylose synthase; NAD+ binding; UDP-glucuronate decarboxylase activity.
  
  
 0.705
Nurf-38
Inorganic pyrophosphatase; Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite; Belongs to the PPase family.
   
  
 0.680
cn
Kynurenine 3-monooxygenase; Cinnabar (cn) encodes the enzyme that synthesizes 3-hydroxykynurenine (3-HK) as part of the kynurenine pathway of tryptophan degradation. 3-HK is an intermediate product in the formation of ommochromes, the brown pigments in the fly eye, and thus cn loss of function mutant flies exhibit altered eye color. Several kynurenine pathway metabolites are neuroactive and have been linked to the pathogenesis of neurodegenerative disorders.
      
 0.680
nst
Nesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling.
  
  
 0.672
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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