STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG31633LD20162p; Ubiquitin-protein transferase activity. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (408 aa)    
Predicted Functional Partners:
Fbw5
F-box and WD repeat domain containing 5 (Fbw5) targets proteins for destruction via its role as a substrate receptor for the CRL4 E3 ubiquitin ligase. A key target of Fbw5 is the gig subunit of the Tuberous Sclerosis complex, an important negative regulator of cellular growth via inhibition of the TOR kinase pathway
     
 0.911
morgue
Modifier of rpr and grim, ubiquitously expressed; Ubiquitin-protein transferase activity; K48-linked polyubiquitin binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; apoptotic process; positive regulation of compound eye retinal cell apoptotic process; regulation of retinal cell programmed cell death; Belongs to the ubiquitin-conjugating enzyme family
     
 0.850
Skp2
annotation not available
     
 0.792
Roc1a
Regulator of cullins 1a (Roc1a) is a C2H2 type zinc finger protein and component of several Cullin-Ring E3 ubiquitin ligase complexes. Roc1a binds directly to the Cullin subunit within the CRL complex and functions to recruit ubiquitin-charged E2 proteins
     
 0.779
Cul1
Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larva [...]
     
 0.770
SkpA
SKP1-related A (SkpA) is a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication; Belongs to the SKP1 family
     
 0.764
CG6758
GH02866p; Ubiquitin-protein transferase activity. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
     
  0.720
Ppa
Partner of paired (Ppa) is involved in response to oxidative stress
     
  0.720
SkpF
Ubiquitin-protein transferase activity. It is involved in the biological process described with: protein ubiquitination involved in ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family
     
  0.720
ntc
Protein nutcracker; Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability
     
  0.720
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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