STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rca1Regulator of cyclin A1; Ubiquitin-protein transferase activity. It is involved in the biological process described with: negative regulation of mitotic anaphase-promoting complex activity; eye-antennal disc morphogenesis; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; lateral inhibition; neurogenesis; regulation of mitosis; G1/S transition of mitotic cell cycle (411 aa)    
Predicted Functional Partners:
rap
Retina aberrant in pattern (Rap) binds to the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase to stimulate its activity during G1 phase
   
 
 0.938
CycA
G2/mitotic-specific cyclin-A; Cyclin A (CycA) binds to Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity
   
 
 0.915
SkpA
SKP1-related A (SkpA) is a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication; Belongs to the SKP1 family
    
 0.913
Cul1
Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larva [...]
   
 0.905
polo
Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules
   
 
 0.904
Cdk1
Cyclin-dependent kinase (Cdk1) is a catalytic protein kinase subunit that can only become active after association with either CycA, CycB or CycB3. The protein kinase activities of these complexes (CycA-Cdk1, CycB-Cdk1, CycB3-Cdk1) control important aspects of progression through the cell cycle. Functionally, the different Cdk1 complexes are partially redundant. They phosphorylate hundreds of target proteins and are most important for progression into and through mitotic and meiotic M phases; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
   
  
 0.876
fzy
FI02843p; Mitotic anaphase-promoting complex activity
   
 
 0.875
Skp2
annotation not available
     
 0.867
geminin
Geminin, isoform A; DNA binding. It is involved in the biological process described with: eggshell chorion gene amplification; regulation of syncytial blastoderm mitotic cell cycle; endomitotic cell cycle; regulation of cell cycle; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of DNA replication
   
  
 0.835
SkpB
Ubiquitin-protein transferase activity. It is involved in the biological process described with: protein ubiquitination involved in ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family
    
 0.792
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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