STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nuf2Nuf2; It is involved in the biological process described with: mitotic spindle organization; mitotic metaphase plate congression; neurogenesis; chromosome segregation (395 aa)    
Predicted Functional Partners:
Spc25
Kinetochore protein Spc25; Acts as a component of the essential kinetochore- associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...]
   
 0.995
Ndc80
LD33040p; It is involved in the biological process described with: spindle assembly involved in mitosis; mitotic spindle organization; mitotic metaphase plate congression; neurogenesis; chromosome segregation
   
 0.990
Kmn1
Kinetochore Mis12-Ndc80 network component 1, isoform A; It is involved in the biological process described with: mitotic chromosome movement towards spindle pole; mitotic metaphase plate congression; neurogenesis; chromosome segregation
   
 0.988
Mis12
RE19545p; It is involved in the biological process described with: mitotic chromosome movement towards spindle pole; mitotic spindle organization; mitotic metaphase plate congression; neurogenesis; chromosome segregation
   
 0.982
Nnf1b
RE44027p; Nnf1b is a component of the Mis12 complex, an essential constituent of the kinetochore
   
 0.980
Nnf1a
RE42502p; Nnf1a is a component of the Mis12 complex, an essential constituent of the kinetochore
   
 0.976
Kmn2
Kinetochore Mis12-Ndc80 network component 2 is a component of the Ndc80 complex, an essential kinetochore constituent
     
 0.957
mad2
RE72064p; Mad2 is a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, Mad2 is intranuclear, bound to Mad1, and associated primarily with the nuclear pore complex
   
  
 0.932
Spc105R
Spc105-related, isoform B; Spc105-related (Spc105R) is an essential component of the kinetochore, to which it is recruited by binding to the Mis12 kinetochore complex. Spc105R and Mis12 recruit the Ndc80 complex, which provides the major microtubule binding activity of the kinetochore
   
 
 0.898
BubR1
Bub1-related kinase (BubR1) is a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, BubR1 plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. BubR1 is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females
   
  
 0.798
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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