STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Akap200A-kinase anchor protein 200; Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability b [...] (837 aa)    
Predicted Functional Partners:
Pka-R2
cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain.
    
 
 0.675
Caper
Caper, isoform A; Caper (Caper) encodes an RNA-binding protein involved in regulation of alternative mRNA splicing.
   
  
 0.554
fax
Failed axon connections; Together with Abl, involved in embryonic axonal development.
   
 
 0.536
ng2
annotation not available
      
 0.525
Tsp42Eg
Tetraspanin.
      
 0.521
CG10082
Kinase activity; inositol hexakisphosphate kinase activity. It is involved in the biological process described with: phosphatidylinositol phosphorylation; inositol phosphate biosynthetic process; Belongs to the inositol phosphokinase (IPK) family.
   
  
 0.500
CAH4
Carbonic anhydrase 4, isoform A; Zinc ion binding; hydro-lyase activity; carbonate dehydratase activity. It is involved in the biological process described with: one-carbon metabolic process; Belongs to the alpha-carbonic anhydrase family.
   
  
 0.494
Lnpk
Lunapark, isoform A; It is involved in the biological process described with: endoplasmic reticulum tubular network organization.
    
 
 0.492
CG5757
CG5757-PA; Thymidylate kinase activity; ATP binding; nucleoside diphosphate kinase activity; uridylate kinase activity. It is involved in the biological process described with: dUDP biosynthetic process; dTTP biosynthetic process; dTDP biosynthetic process.
   
  
 0.464
CG10459
Uncharacterized protein.
    
 
 0.463
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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