STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
peloProtein pelota; Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis. It is also required for normal eye patterning and for mitotic divisions in the ovary. Required for ovarian germ line stem cell self-renewal. May play a role in regulating translation. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). (395 aa)    
Predicted Functional Partners:
HBS1
HBS1, isoform A; HBS1 (HBS1) encodes an elongation factor class G protein that is implicated in messenger RNA quality control, by forming a protein complex with the product of pelo to promote decay of mRNAs with ribosomal stalls.
   
 
 0.999
pix
Pixie, isoform A; Pixie (pix) encodes ABCE1, which is an ATPase that functions as a translation recycling factor. It is required for the assembly of complexes involved in translation initiation, and plays a role in the regulation of cellular and organismal growth.
  
 
 0.993
eRF3
Eukaryotic translation release factor 3 (eRF3) encodes a GTP-binding protein important in the termination of protein translation.
   
 
 0.968
Rack1
Guanine nucleotide-binding protein subunit beta-like protein; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).
    
 
 0.960
RpS30
40S ribosomal protein S30; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eS30 family.
    
 
 0.944
RpS6
40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
   
 
 0.942
RpS20
40S ribosomal protein S20; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation.
    
 
 0.923
RpS3
Ribosomal protein S3 (RpS3) encodes a component of the small subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpS3 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. The product of RpS3 also contains a DNA lyase activity and functions in DNA repair.
   
 
 0.923
RpL7A
Ribosomal protein L7A (RpL7A) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL8 family.
   
 
 0.920
RpL38
Ribosomal protein L38 (RpL38) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL38 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles.
    
 
 0.915
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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