STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Srp54LD29830p; mRNA binding; poly-pyrimidine tract binding; nucleotide binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; mRNA splice site selection; neurogenesis (513 aa)    
Predicted Functional Partners:
Rbp1
RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site; Belongs to the splicing factor SR family
   
 0.993
x16
X16 splicing factor, isoform A; mRNA binding; protein binding; RNA binding; zinc ion binding; nucleotide binding; nucleic acid binding. It is involved in the biological process described with: nervous system development; RNA splicing; mRNA splicing, via spliceosome; mRNA splice site selection
   
 0.987
pUf68
Poly(U)-binding-splicing factor half pint; Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF-4E and grk, while it is not involved in the splicing of par-1, sqd and psq; Belongs to the RRM half pint family
   
 0.979
CG10324
FI23980p1; Nucleic acid binding. It is involved in the biological process described with: neurogenesis
   
  0.978
SC35
SR family splicing factor SC35, isoform B; mRNA binding; protein binding; nucleotide binding; nucleic acid binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; mRNA splice site selection
   
 0.972
RnpS1
RNA-binding protein S1; mRNA binding; nucleotide binding; nucleic acid binding. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
   
 0.968
SF2
SR family splicing factor SF2; mRNA binding; protein binding; nucleotide binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA splice site selection; mitotic G2 DNA damage checkpoint; neurogenesis
   
 0.965
Prp19
Pre-RNA processing factor 19; Ubiquitin-protein transferase activity. It is involved in the biological process described with: positive regulation of Ras protein signal transduction; regulation of alternative mRNA splicing, via spliceosome; positive regulation of ERK1 and ERK2 cascade; mRNA splicing, via spliceosome; protein ubiquitination
   
 0.963
CG11107
DHX15 ortholog, isoform A; ATP binding; ATP-dependent helicase activity; ATP-dependent RNA helicase activity; nucleic acid binding; RNA helicase activity. It is involved in the biological process described with: mRNA splicing, via spliceosome; neurogenesis
   
  0.961
CG3436
CG3436, isoform A; It is involved in the biological process described with: mitotic nuclear division; mRNA splicing, via spliceosome
   
  0.960
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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