STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Snx17LD15323p; Phosphatidylinositol binding. It is involved in the biological process described with: retrograde transport, endosome to plasma membrane; intracellular protein transport. (490 aa)    
Predicted Functional Partners:
Snx1
Sorting nexin 1, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol binding. It is involved in the biological process described with: intracellular protein transport; endocytosis; retrograde transport, endosome to Golgi; early endosome to Golgi transport.
   
 
 0.934
Snx3
Sorting nexin 3 (Snx3) encodes a protein involved in the secretion of the morphogen encoded by wg. It regulates the retromer-dependent recycling of the transmembrane cargo encoded by wls.
   
 
 0.923
Vps29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
    
 
 0.903
Snx6
Sorting nexin 6, isoform B; Phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; phagosome-lysosome fusion involved in apoptotic cell clearance.
    
 
 0.897
CG4074
IP10134p.
   
  
 0.860
Vps26
Vacuolar protein sorting-associated protein 26; Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis. Belongs to the VPS26 family.
   
 
 0.827
Vps35
Vacuolar protein sorting 35 (Vps35) encodes a component of the retromer complex that acts to recycle membrane proteins to the Golgi or plasma membrane from endocytosed vesicles.
    
 
 0.824
SH3PX1
Sorting nexin; Phosphatidylinositol-4,5-bisphosphate binding; kinase binding; protein binding; Belongs to the sorting nexin family.
   
  
 0.736
snz
Snazarus, isoform A; Snazarus (snz) encodes a sorting nexin protein involved in lifespan.
      
 0.712
Snx16
Sorting nexin 16 (Snx16) encodes a protein that regulates synaptic growth at the neuromuscular junction.
   
  
 0.710
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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