STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
Bug22Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for sperm individualization, differentiation of the sperm flagellum and tubulin polyglycylation of axonemal microtubules; Belongs to the CFAP20 family (199 aa)    
Predicted Functional Partners:
TfIIB
Transcription factor IIB (TFIIB) is a basal transcription factor that binds to the TATA box-binding protein. TFIIB is required for the initiation of transcription by RNA polymerase II
      
 0.840
TTLL3B
Tubulin glycylase 3B; Essential glycylase which modifies both tubulin and non- tubulin proteins, generating side chains of glycine on the gamma- carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha- tubulin. Has the ability to both mono- and polyglycylate non- tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis
   
 
 0.799
Cep97
annotation not available
   
  
 0.745
TTLL3A
Tubulin glycylase 3A; Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains
   
  
 0.672
Poc1
Proteome of centrioles 1 (Poc1) is a cytoplasmic protein located in the sperm giant centriole and proximal centriole-like structure (PCL), which assists in the elongation of the giant centrioles and recruitment of centriolar proteins to the PCL. Poc1 contributes to sperm motility and fertility
   
  
 0.619
tra2
Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female-specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...]
   
  
 0.582
tex
Tex
   
  
 0.560
Rfx
Rfx, isoform F; Rfx
   
  
 0.558
Cp110
Centriolar coiled coil protein 110kDa, isoform B; Cp110 is a centriolar protein that localizes to the distal end of both mother and daughter centrioles. It seems to prevent the centriole microtubules from extending beyond the distal end of the centriole. Cp110 interacts with Cep97, another protein localized to the distal end of the centrioles
      
 0.551
CG6227
LD41277p; mRNA binding; ATP binding; ATP-dependent RNA helicase activity; RNA helicase activity. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome
   
  
 0.540
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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