Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bub1 | Bub3 | FBpp0309714 | FBpp0308293 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | 0.999 |
| Bub1 | BubR1 | FBpp0309714 | FBpp0085368 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females. | 0.947 |
| Bub1 | Klp61F | FBpp0309714 | FBpp0072616 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] | 0.804 |
| Bub1 | Mps1 | FBpp0309714 | FBpp0303766 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints. | 0.937 |
| Bub1 | Ndc80 | FBpp0309714 | FBpp0073681 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression. | 0.986 |
| Bub1 | Zw10 | FBpp0309714 | FBpp0070425 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Centromere/kinetochore protein zw10; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1. Required for maintenance of Golgi stack number and morphology, and acroblast assembly. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure [...] | 0.896 |
| Bub1 | asp | FBpp0309714 | FBpp0084071 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Protein abnormal spindle; Required to maintain the structure of the centrosomal microtubule organizing center (MTOC) during mitosis. May have a preferential role in regulating neurogenesis. Required for germ cell mitosis and oocyte differentiation. | 0.776 |
| Bub1 | aurA | FBpp0309714 | FBpp0081957 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. | 0.762 |
| Bub1 | aurB | FBpp0309714 | FBpp0079769 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | 0.820 |
| Bub1 | cana | FBpp0309714 | FBpp0079795 | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | CENP-ana, isoform A; CENP-ana (cana) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.940 |
| Bub3 | Bub1 | FBpp0308293 | FBpp0309714 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | 0.999 |
| Bub3 | BubR1 | FBpp0308293 | FBpp0085368 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females. | 0.999 |
| Bub3 | Klp61F | FBpp0308293 | FBpp0072616 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] | 0.523 |
| Bub3 | Mps1 | FBpp0308293 | FBpp0303766 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints. | 0.944 |
| Bub3 | Ndc80 | FBpp0308293 | FBpp0073681 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression. | 0.902 |
| Bub3 | Zw10 | FBpp0308293 | FBpp0070425 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | Centromere/kinetochore protein zw10; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores. During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1. Required for maintenance of Golgi stack number and morphology, and acroblast assembly. Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex. Failure [...] | 0.918 |
| Bub3 | aurA | FBpp0308293 | FBpp0081957 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | Aurora A (aurA) encodes a protein kinase required for proper neuroblast self-renewal by regulating assymmetric protein localization. It contributes to spindle orientation, centrosome separation and pole cell formation. | 0.845 |
| Bub3 | aurB | FBpp0308293 | FBpp0079769 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | 0.957 |
| Bub3 | cana | FBpp0308293 | FBpp0079795 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. | CENP-ana, isoform A; CENP-ana (cana) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.886 |
| BubR1 | Bub1 | FBpp0085368 | FBpp0309714 | Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females. | Bub1 kinase (Bub1) encodes a spindle checkpoint protein regulating chromosome congression. It also contributes to clathrin-dependent endocytosis of pathogens. | 0.947 |
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