STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG6201LD15174p; L-iduronidase activity; hydrolase activity, hydrolyzing O-glycosyl compounds. It is involved in the biological process described with: carbohydrate metabolic process. (636 aa)    
Predicted Functional Partners:
Sgsh
RE63280p; Sulfuric ester hydrolase activity; N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding; N-sulfoglucosamine sulfohydrolase activity. It is involved in the biological process described with: heparan sulfate proteoglycan catabolic process; glycosaminoglycan catabolic process.
   
 
 0.930
CG7402
Sulfatase domain-containing protein; Sulfuric ester hydrolase activity.
   
 
 0.921
CG8646
RE14504p; Sulfuric ester hydrolase activity.
   
 
 0.921
Ids
Iduronate-2-sulfatase activity; sulfuric ester hydrolase activity.
     
 0.904
SNF4Agamma
SNF4/AMP-activated protein kinase gamma subunit (SNF4Agamma) encodes a protein involved in lipid metabolism, autophagy and response to starvation.
   
 
 0.626
alc
Alicorn, isoform A; Protein kinase binding. It is involved in the biological process described with: regulation of catalytic activity; maintenance of apical/basal cell polarity; neuron cellular homeostasis.
    
 
 0.620
TyrRS
tRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation.
      
 0.602
CG17119
Cystinosin homolog; Thought to transport cystine out of lysosomes; Belongs to the cystinosin family.
   
  
 0.580
CG13397
LP03571p; alpha-N-acetylglucosaminidase activity.
   
  
 0.450
CG7840
Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).
   
  
 0.408
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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