STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hsp60DHeat shock protein 60D (Hsp60D) encodes a protein involved in caspase-mediated apoptosis and polyQ-mediated neurodegeneration; Belongs to the chaperonin (HSP60) family. (558 aa)    
Predicted Functional Partners:
CG9920
AT30951p; Chaperone binding; unfolded protein binding; metal ion binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding; Belongs to the GroES chaperonin family.
  
 
 0.926
Hsc70-5
Heat shock 70 kDa protein cognate 5.
  
 
 0.913
CG11267
RH34413p; Metal ion binding; unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding; Belongs to the GroES chaperonin family.
  
 
 0.901
CCT8
Chaperonin containing TCP1 subunit 8; Unfolded protein binding; ATP binding. It is involved in the biological process described with: protein folding.
   
 
 0.830
Roe1
GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
  
 
 0.802
CCT1
T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
   
  
 0.722
Hsp70Bc
Heat-shock-protein-70Bc (Hsp70Bc) encodes a protein involved in response to heat shock, hypoxia and drugs.
  
 
 0.720
Gp93
Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development.
   
 
 0.718
Hsp83
Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...]
   
 
 0.669
Lon
Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Regulates mitochondrial DNA (mtDNA) copy number and transcription by [...]
  
 
 0.666
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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