STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rab14Rab14, isoform B; Rab14 (Rab14) encodes a protein involved in phagocytosis, phagolysosome assembly and phagosome acidification. (239 aa)    
Predicted Functional Partners:
Gdi
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
   
 0.861
Rep
Rab proteins geranylgeranyltransferase component A; Binds unprenylated Rab proteins, presents it to the catalytic component B, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab to a protein acceptor (By similarity).
    
 0.752
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
  
 
 0.750
Klp98A
Kinesin-like protein Klp98A; Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa si [...]
    
 
 0.733
Vps50
Vacuolar protein sorting 50; It is involved in the biological process described with: endocytic recycling; retrograde transport, endosome to Golgi.
      
 0.652
RabX5
RabX5; GTP binding; GTPase activity. It is involved in the biological process described with: vesicle-mediated transport; Rab protein signal transduction; intracellular protein transport.
  
0.643
Ccz1
Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes.
      
 0.628
Fbp2
Fat body protein 2 (Fbp2) encodes a 256 amino acid protein that accumulates in the larval fat-body at the third larval and pupal stages. The product of Fbp2 is related to the alcohol dehydrogenase encoded by Adh but has no known enzymatic function. The Fbp2-encoded polypeptide contains 20% methionine, whereas there are no methionines in mature polypeptide encoded by Adh, therefore it is thought to be a sulfur-storage protein at metamorphosis; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
   0.616
Rab6
Ras-related protein Rab6; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regula [...]
  
0.612
CG8230
Dymeclin; It is involved in the biological process described with: Golgi organization; Belongs to the dymeclin family.
      
 0.609
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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