STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Idgf1Chitinase-like protein Idgf1; Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex. (439 aa)    
Predicted Functional Partners:
Idgf2
Chitinase-like protein Idgf2; Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex; Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.
  
  
0.619
CG15202
Uncharacterized protein, isoform A.
      
 0.603
Tsp42Eg
Tetraspanin.
   
  
 0.527
Spn88Eb
CG6687 protein; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: response to fungus; negative regulation of endopeptidase activity; epithelium regeneration; regulation of stem cell division; negative regulation of proteolysis; Belongs to the serpin family.
   
  
 0.525
obst-A
Obstructor-A, isoform A; obstructor-A (obst-A) encodes a protein that forms a core complex with chitin and the chitin modifying proteins encoded by serp and knk. This complex is required for assembly, maturation and preservation of the chitinous cuticles at the end of embryogenesis and probably throughout larval development.
      
 0.495
CG17739
GH02025p; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: cell adhesion.
   
  
 0.495
CG4250
Uncharacterized protein, isoform B.
   
  
 0.463
CG18787
C3H1-type domain-containing protein; Nuclear localization sequence binding; RNA binding; metal ion binding; structural constituent of nuclear pore. It is involved in the biological process described with: protein import into nucleus; RNA export from nucleus; telomere tethering at nuclear periphery; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery.
      
 0.450
CG4563
RE01528p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process.
      
 0.439
Cht12
Chitinase 12 (Cht12) encodes an enzyme involved in cuticle development, ecdysis and wound healing; Belongs to the glycosyl hydrolase 18 family.
 
   
0.436
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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