STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tosExonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). (732 aa)    
Predicted Functional Partners:
CG2990
FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal.
   
 
 0.998
Mlh1
Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair.
   
 0.998
Msh6
Probable DNA mismatch repair protein Msh6; Msh6 (Msh6) encodes a heterodimer with the product of spel1 to detect base-base mismatches and small insertion/deletion loops. It then recruits the rest of the mismatch repair machinery.
   
 0.995
spn-A
DNA repair protein Rad51 homolog; Spindle A (spn-A) encodes a protein that forms a filament on single-stranded DNA, does a homology search of double-stranded DNA, and catalyzes strand exchange, swapping the single-strand DNA in and displacing the partner of the complementary strand.
  
 
 0.994
Pms2
Pms2; Mismatched DNA binding; ATPase activity; ATP binding. It is involved in the biological process described with: mismatch repair.
   
 0.992
RecQ4
RecQ4 helicase (RecQ4) encodes an important protein for genome stability and DNA metabolism. It can utilize energy from ATP hydrolysis to help the DNA strand separation and exchange, playing a critical role in replication and repair.
  
 
 0.991
DNAlig1
DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 
 0.987
mus81
EG:BACR7A4.16 protein; Mus81 (mus81) encodes the catalytic subunit of the Mus81-mms4 structure-selective endonuclease that functions in DNA repair.
   
 
 0.985
mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
  
 
 0.983
spel1
DNA mismatch repair protein spellchecker 1; Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity).
   
 0.983
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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