STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
l(2)37CcProtein l(2)37Cc; Required for larval metabolism or for the progression of the larva into a pupa; Belongs to the prohibitin family. (276 aa)    
Predicted Functional Partners:
Phb2
Prohibitin.
  
0.999
Spg7
Paraplegin, isoform A; Metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; ATPase activity; ATP binding. It is involved in the biological process described with: mitochondrion organization; proteolysis.
   
 0.964
CG6512
SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion.
   
 0.931
CG8728
GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing.
  
 0.817
YME1L
ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...]
   
 
 0.816
Hsc70-5
Heat shock 70 kDa protein cognate 5.
   
 
 0.771
eEF5
Eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis; Belongs to the eIF-5A family.
  
 
 0.766
Stoml2
Stomatin like 2, isoform A.
   
 
 0.759
14-3-3zeta
14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes.
   
 0.735
sta
40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development. Belongs to the universal ribosomal protein uS2 family.
   
 
 0.728
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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