node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
14-3-3zeta | Hsc70-5 | FBpp0087500 | FBpp0086694 | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | Heat shock 70 kDa protein cognate 5. | 0.537 |
14-3-3zeta | Phb2 | FBpp0087500 | FBpp0111775 | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | Prohibitin. | 0.452 |
14-3-3zeta | l(2)37Cc | FBpp0087500 | FBpp0312093 | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | Protein l(2)37Cc; Required for larval metabolism or for the progression of the larva into a pupa; Belongs to the prohibitin family. | 0.735 |
CG6512 | CG8728 | FBpp0075012 | FBpp0087958 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | 0.855 |
CG6512 | Hsc70-5 | FBpp0075012 | FBpp0086694 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Heat shock 70 kDa protein cognate 5. | 0.679 |
CG6512 | Phb2 | FBpp0075012 | FBpp0111775 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Prohibitin. | 0.895 |
CG6512 | Spg7 | FBpp0075012 | FBpp0311759 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Paraplegin, isoform A; Metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; ATPase activity; ATP binding. It is involved in the biological process described with: mitochondrion organization; proteolysis. | 0.956 |
CG6512 | Stoml2 | FBpp0075012 | FBpp0072054 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Stomatin like 2, isoform A. | 0.699 |
CG6512 | YME1L | FBpp0075012 | FBpp0293463 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | 0.751 |
CG6512 | l(2)37Cc | FBpp0075012 | FBpp0312093 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | Protein l(2)37Cc; Required for larval metabolism or for the progression of the larva into a pupa; Belongs to the prohibitin family. | 0.931 |
CG6512 | sta | FBpp0075012 | FBpp0070277 | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | 40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Required during oogenesis and imaginal development. Belongs to the universal ribosomal protein uS2 family. | 0.495 |
CG8728 | CG6512 | FBpp0087958 | FBpp0075012 | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | 0.855 |
CG8728 | Hsc70-5 | FBpp0087958 | FBpp0086694 | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | Heat shock 70 kDa protein cognate 5. | 0.470 |
CG8728 | Phb2 | FBpp0087958 | FBpp0111775 | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | Prohibitin. | 0.719 |
CG8728 | Spg7 | FBpp0087958 | FBpp0311759 | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | Paraplegin, isoform A; Metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; ATPase activity; ATP binding. It is involved in the biological process described with: mitochondrion organization; proteolysis. | 0.811 |
CG8728 | YME1L | FBpp0087958 | FBpp0293463 | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | 0.528 |
CG8728 | l(2)37Cc | FBpp0087958 | FBpp0312093 | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | Protein l(2)37Cc; Required for larval metabolism or for the progression of the larva into a pupa; Belongs to the prohibitin family. | 0.817 |
Hsc70-5 | 14-3-3zeta | FBpp0086694 | FBpp0087500 | Heat shock 70 kDa protein cognate 5. | 14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes. | 0.537 |
Hsc70-5 | CG6512 | FBpp0086694 | FBpp0075012 | Heat shock 70 kDa protein cognate 5. | SD01613p; Metalloendopeptidase activity; zinc ion binding; ATP binding. It is involved in the biological process described with: protein-containing complex assembly; cristae formation; mitochondrial protein processing; proteolysis; mitochondrial fusion. | 0.679 |
Hsc70-5 | CG8728 | FBpp0086694 | FBpp0087958 | Heat shock 70 kDa protein cognate 5. | GH09295p; Metal ion binding; endopeptidase activity; metalloendopeptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion; protein processing. | 0.470 |