node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG2614 | TM9SF2 | FBpp0080918 | FBpp0307148 | eEF1A lysine and N-terminal methyltransferase homolog; Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus. Belongs to the methyltransferase superfamily. | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.437 |
CG4972 | TM9SF2 | FBpp0079578 | FBpp0307148 | Nicalin; It is involved in the biological process described with: regulation of signal transduction; Belongs to the nicastrin family. | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.441 |
GABA-B-R3 | TM9SF2 | FBpp0310350 | FBpp0307148 | Metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.628 |
Glg1 | TM9SF2 | FBpp0304963 | FBpp0307148 | Golgi complex-localized glycoprotein 1, isoform B; Fibroblast growth factor binding. | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.548 |
PGRP-LC | PGRP-LE | FBpp0088492 | FBpp0300347 | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] | Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] | 0.969 |
PGRP-LC | PGRP-LF | FBpp0088492 | FBpp0076167 | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] | Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. | 0.990 |
PGRP-LC | TM9SF2 | FBpp0088492 | FBpp0307148 | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.707 |
PGRP-LE | PGRP-LC | FBpp0300347 | FBpp0088492 | Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] | 0.969 |
PGRP-LE | PGRP-LF | FBpp0300347 | FBpp0076167 | Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] | Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. | 0.460 |
PGRP-LE | TM9SF2 | FBpp0300347 | FBpp0307148 | Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.456 |
PGRP-LF | PGRP-LC | FBpp0076167 | FBpp0088492 | Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] | 0.990 |
PGRP-LF | PGRP-LE | FBpp0076167 | FBpp0300347 | Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. | Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] | 0.460 |
PGRP-LF | TM9SF2 | FBpp0076167 | FBpp0307148 | Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.541 |
Spt-I | TM9SF2 | FBpp0086842 | FBpp0307148 | Pyridoxal phosphate binding; serine C-palmitoyltransferase activity. It is involved in the biological process described with: positive regulation of sphingolipid biosynthetic process; ceramide biosynthetic process; sphingosine biosynthetic process. | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.489 |
TM9SF2 | CG2614 | FBpp0307148 | FBpp0080918 | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | eEF1A lysine and N-terminal methyltransferase homolog; Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus. Belongs to the methyltransferase superfamily. | 0.437 |
TM9SF2 | CG4972 | FBpp0307148 | FBpp0079578 | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | Nicalin; It is involved in the biological process described with: regulation of signal transduction; Belongs to the nicastrin family. | 0.441 |
TM9SF2 | GABA-B-R3 | FBpp0307148 | FBpp0310350 | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | Metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms. | 0.628 |
TM9SF2 | Glg1 | FBpp0307148 | FBpp0304963 | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | Golgi complex-localized glycoprotein 1, isoform B; Fibroblast growth factor binding. | 0.548 |
TM9SF2 | PGRP-LC | FBpp0307148 | FBpp0088492 | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] | 0.707 |
TM9SF2 | PGRP-LE | FBpp0307148 | FBpp0300347 | Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...] | 0.456 |