STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM9SF2Transmembrane 9 superfamily member; It is involved in the biological process described with: protein localization to membrane; negative regulation of peptidoglycan recognition protein signaling pathway; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (659 aa)    
Predicted Functional Partners:
PGRP-LC
Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...]
    
 
 0.707
GABA-B-R3
Metabotropic GABA-B receptor subtype 3 (GABA-B-R3) encodes a G-protein coupled receptor for the GABA neurotransmitter that is coupled to the Go G protein and activation of phospholipase C. Activation of the product of GABA-B-R3 can inhibit neuronal activity. It functions in the olfactory system and in the regulation of sleep and circadian rhythms.
      
 0.628
Glg1
Golgi complex-localized glycoprotein 1, isoform B; Fibroblast growth factor binding.
   
  
 0.548
PGRP-LF
Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC.
      
 0.541
bai
Transmembrane emp24 domain-containing protein bai; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected; Belongs to the EMP24/GP25L family.
   
  
 0.495
Spt-I
Pyridoxal phosphate binding; serine C-palmitoyltransferase activity. It is involved in the biological process described with: positive regulation of sphingolipid biosynthetic process; ceramide biosynthetic process; sphingosine biosynthetic process.
   
  
 0.489
UGP
UTP--glucose-1-phosphate uridylyltransferase; UGP (UGP) encodes an enzyme involved in hyperoxia response.
   
  
 0.476
PGRP-LE
Peptidoglycan-recognition protein LE; Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram- negative bacteria and activating the imd/Relish pathway. Has no activity against on Gram-positive bacteria. Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway. Functions synergistically with PGRP-LC in producing resistance to E.coli and B.megaterium infections, which have the DAP-type peptidoglycan. Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is req [...]
   
  
 0.456
CG4972
Nicalin; It is involved in the biological process described with: regulation of signal transduction; Belongs to the nicastrin family.
   
    0.441
CG2614
eEF1A lysine and N-terminal methyltransferase homolog; Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus. Belongs to the methyltransferase superfamily.
   
  
 0.437
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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