STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Syt4Synaptotagmin 4 is a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment (474 aa)    
Predicted Functional Partners:
Syt1
Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone
   
0.974
shi
Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family
   
 
 0.971
nSyb
Neuronal synaptobrevin, isoform J; SNAP receptor activity; protein binding; SNARE binding. It is involved in the biological process described with: vesicle-mediated transport; synaptic vesicle docking involved in exocytosis; vesicle fusion; neurotransmitter secretion
   
 0.969
Synj
Synaptojanin, isoform A; Synaptojanin (Synj) is a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle
   
 
 0.963
Syb
Synaptobrevin; Unknown, but synaptobrevins are presumed to be involved in targeting and fusion of synaptic vesicles with the presynaptic membrane as well as in neurotransmitter release
   
 0.942
Hip1
Huntingtin interacting protein 1, isoform A; Phospholipid binding; actin binding. It is involved in the biological process described with: cytoskeleton organization
   
 
 0.939
Rab5
Rab5, isoform A; Rab5 is a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering Rab5 activity affects many receptor-mediated signaling pathways as well as epithelial polarity
     
 0.936
stnB
Protein stoned-B; Adapter protein involved in endocytic recycling of synaptic vesicles membranes. May act by mediating the retrieval of synaptotagmin protein Syt from the plasma membrane, thereby facilitating the internalization of multiple synaptic vesicles from the plasma membrane
   
 0.936
aux
Auxilin, isoform A; Protein kinase activity; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: synaptic vesicle uncoating; protein phosphorylation; compound eye morphogenesis; sperm individualization; Notch signaling pathway
     
 0.930
lap
Phosphatidylinositol-binding clathrin assembly protein LAP; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction; Belongs to the PICALM/SNAP91 family
   
 
 0.927
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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