STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AmaProtein amalgam. (341 aa)    
Predicted Functional Partners:
Nrt
Neurotactin; May mediate or modulate cell adhesion between embryonic cells during development; In the C-terminal section; belongs to the type-B carboxylesterase/lipase family.
   
 
 0.928
Dtg
Dpp target protein; It is involved in the biological process described with: gastrulation.
   
    0.844
Tom
Twin of m4 (Tom) is a member of the Bearded gene family that encodes a regulator of the Notch signaling pathway.
   
    0.753
bnb
Protein bangles and beads; May play an important role during development.
   
 
 0.551
CG9962
IP11482p; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: peptidyl-serine phosphorylation; negative regulation of canonical Wnt signaling pathway; protein phosphorylation.
      
 0.533
Wdfy2
WD repeat and FYVE domain containing 2, isoform A; Protein kinase binding; metal ion binding.
    
   0.513
otk
Tyrosine-protein kinase-like otk; Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
   
 
0.499
SP2353
SP2353, isoform A; SP2353 (SP2353) encodes a EGF-like- and LamininG-domain-containing protein. It interacts genetically with Dg, which encodes a extracellular matrix receptor. It regulates muscle homeostasis, rhabdomere differentiation and innate immune response.
      
 0.493
beat-Vc
Beaten path Vc; It is involved in the biological process described with: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; motor neuron axon guidance.
      
 0.493
Inx3
Innexin 3 (Inx3) encodes a gap junction protein that can form heteromeric gap junction channels via interaction with the product of Inx2. Loss of Inx3 leads to the destabilization of the products of ogre, Inx2 and shg at the plasma membrane, suggesting that these four proteins form a complex.
   
  
 0.490
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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