node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG10778 | CG9272 | FBpp0071083 | FBpp0088883 | Alkyl transferase; Dehydrodolichyl diphosphate synthase activity; polyprenyltransferase activity. It is involved in the biological process described with: polyprenol biosynthetic process; Belongs to the UPP synthase family. | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.516 |
CG10778 | Mlh1 | FBpp0071083 | FBpp0087867 | Alkyl transferase; Dehydrodolichyl diphosphate synthase activity; polyprenyltransferase activity. It is involved in the biological process described with: polyprenol biosynthetic process; Belongs to the UPP synthase family. | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | 0.414 |
CG10778 | agt | FBpp0071083 | FBpp0312542 | Alkyl transferase; Dehydrodolichyl diphosphate synthase activity; polyprenyltransferase activity. It is involved in the biological process described with: polyprenol biosynthetic process; Belongs to the UPP synthase family. | O-6-alkylguanine-DNA alkyltransferase (agt) encodes a methylated-DNA-cysteine S-methyltransferase involved in DNA repair. | 0.921 |
CG17807 | Ogg1 | FBpp0071849 | FBpp0071168 | Fe2OG dioxygenase domain-containing protein; Nucleic acid binding; tRNA (uracil) methyltransferase activity; 2-oxoglutarate-dependent dioxygenase activity. It is involved in the biological process described with: tRNA methylation; oxidation-reduction process; tRNA wobble uridine modification. | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Efficiently incises DNA duplexes containing 8-hydroxyguanine (8-OH-Gua), 8-hydroxyadenine (8- OH-Ade) and abasic (AP) sites placed opposite to a cytosine. | 0.695 |
CG17807 | agt | FBpp0071849 | FBpp0312542 | Fe2OG dioxygenase domain-containing protein; Nucleic acid binding; tRNA (uracil) methyltransferase activity; 2-oxoglutarate-dependent dioxygenase activity. It is involved in the biological process described with: tRNA methylation; oxidation-reduction process; tRNA wobble uridine modification. | O-6-alkylguanine-DNA alkyltransferase (agt) encodes a methylated-DNA-cysteine S-methyltransferase involved in DNA repair. | 0.761 |
CG6094 | Mlh1 | FBpp0307934 | FBpp0087867 | CG6094 protein; aminoacyl-tRNA hydrolase activity; translation release factor activity, codon nonspecific. It is involved in the biological process described with: mitochondrial translational termination. | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | 0.581 |
CG6094 | agt | FBpp0307934 | FBpp0312542 | CG6094 protein; aminoacyl-tRNA hydrolase activity; translation release factor activity, codon nonspecific. It is involved in the biological process described with: mitochondrial translational termination. | O-6-alkylguanine-DNA alkyltransferase (agt) encodes a methylated-DNA-cysteine S-methyltransferase involved in DNA repair. | 0.684 |
CG9272 | CG10778 | FBpp0088883 | FBpp0071083 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | Alkyl transferase; Dehydrodolichyl diphosphate synthase activity; polyprenyltransferase activity. It is involved in the biological process described with: polyprenol biosynthetic process; Belongs to the UPP synthase family. | 0.516 |
CG9272 | Mlh1 | FBpp0088883 | FBpp0087867 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | 0.727 |
CG9272 | Msh6 | FBpp0088883 | FBpp0075399 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | Probable DNA mismatch repair protein Msh6; Msh6 (Msh6) encodes a heterodimer with the product of spel1 to detect base-base mismatches and small insertion/deletion loops. It then recruits the rest of the mismatch repair machinery. | 0.691 |
CG9272 | Ogg1 | FBpp0088883 | FBpp0071168 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Efficiently incises DNA duplexes containing 8-hydroxyguanine (8-OH-Gua), 8-hydroxyadenine (8- OH-Ade) and abasic (AP) sites placed opposite to a cytosine. | 0.984 |
CG9272 | Pif1 | FBpp0088883 | FBpp0309921 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. | 0.549 |
CG9272 | agt | FBpp0088883 | FBpp0312542 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | O-6-alkylguanine-DNA alkyltransferase (agt) encodes a methylated-DNA-cysteine S-methyltransferase involved in DNA repair. | 0.697 |
CG9272 | mre11 | FBpp0088883 | FBpp0079802 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.495 |
Mlh1 | CG10778 | FBpp0087867 | FBpp0071083 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | Alkyl transferase; Dehydrodolichyl diphosphate synthase activity; polyprenyltransferase activity. It is involved in the biological process described with: polyprenol biosynthetic process; Belongs to the UPP synthase family. | 0.414 |
Mlh1 | CG6094 | FBpp0087867 | FBpp0307934 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | CG6094 protein; aminoacyl-tRNA hydrolase activity; translation release factor activity, codon nonspecific. It is involved in the biological process described with: mitochondrial translational termination. | 0.581 |
Mlh1 | CG9272 | FBpp0087867 | FBpp0088883 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.727 |
Mlh1 | Msh6 | FBpp0087867 | FBpp0075399 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | Probable DNA mismatch repair protein Msh6; Msh6 (Msh6) encodes a heterodimer with the product of spel1 to detect base-base mismatches and small insertion/deletion loops. It then recruits the rest of the mismatch repair machinery. | 0.999 |
Mlh1 | Ogg1 | FBpp0087867 | FBpp0071168 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Efficiently incises DNA duplexes containing 8-hydroxyguanine (8-OH-Gua), 8-hydroxyadenine (8- OH-Ade) and abasic (AP) sites placed opposite to a cytosine. | 0.725 |
Mlh1 | Pif1 | FBpp0087867 | FBpp0309921 | Mlh1, isoform A; ATP binding; ATPase activity; mismatched DNA binding. It is involved in the biological process described with: mismatch repair. | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. | 0.540 |