STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ranshiRanshi (ranshi) encodes a protein involved in oocyte differentiation. (346 aa)    
Predicted Functional Partners:
mago
Protein mago nashi; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton.
   
 0.901
tsu
RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte. Belongs to the RBM8A family.
   
 
 0.865
Srrm1
FI04407p; SRm160 (SRm160) encodes a conserved RNA-binding protein that participates in the exon junction complex and is involved in pre-mRNA splicing and 3' end formation. It participates in somatic sex determination, cell death, retinal development and the control of circadian rhythm. Direct targets include rl.
    
  0.729
Pym
Partner of Y14 and mago; Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit [...]
   
 
  0.728
CG31457
LD10183p; Protein phosphatase 1 binding; zinc ion binding.
   
  
 0.684
EndoB
Endophilin B (EndoB) encodes a protein belonging to the endophilin protein family that functions in the process of membrane binding and deformation. It contributes to oogenesis and fecundity.
   
  
 0.673
CG8223
Protein NASP homolog; Histone binding. It is involved in the biological process described with: DNA replication-dependent nucleosome assembly; CENP-A containing nucleosome assembly; Belongs to the NASP family.
   
 
 0.610
CG10274
Uncharacterized protein; DNA binding; zinc ion binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
 
0.588
D19B
GH09076p; DNA binding; DNA-binding transcription factor activity; zinc ion binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
  
0.583
CG7386
FI21277p1; DNA binding; zinc ion binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
 
0.569
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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