STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ranshiRanshi; Zinc ion binding; nucleic acid binding. It is involved in the biological process described with: oocyte differentiation; germarium-derived oocyte differentiation (346 aa)    
Predicted Functional Partners:
mago
Protein mago nashi; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton
   
 0.921
tsu
RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte; Belongs to the RBM8A family
   
 
 0.882
SRm160
FI04407p; It is involved in the biological process described with: mRNA splicing, via spliceosome; mRNA processing
   
  0.738
Pym
Partner of Y14 and mago; Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal uni [...]
   
 
  0.734
CG8223
annotation not available
   
 
 0.682
EndoB
Endophilin B, isoform A; Endophilin B (EndoB) belongs to the endophilin protein family and functions in the process of membrane binding and deformation. EndoB contributes to oogenesis and fecundity
   
 
 0.614
Pnn
Pinin, isoform B; It is involved in the biological process described with: RNA processing; mRNA splicing, via spliceosome
   
 
  0.572
Upf2
RE04053p; Upf2 is required for nonsense-mediated mRNA decay (NMD). Upf2 interacts directly with Upf1 to identify and degrade NMD-substrate mRNAs, including mRNAs containing premature termination codons and a number of normal endogenous mRNAs
    
  0.548
btz
Barentsz, isoform B; Barentsz (Btz) is a component of the exon junction complex that is recruited to spliced mRNAs to mark where introns have been removed. Btz is required for the posterior localization of osk mRNA
     
  0.540
CG2162
annotation not available
     
  0.540
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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