STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG11964LD41978p. (581 aa)    
Predicted Functional Partners:
c12.1
Protein CWC15 homolog; Involved in pre-mRNA splicing.
   
 0.992
Cdc5
Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.992
Tango4
Transport and golgi organization 4; It is involved in the biological process described with: mRNA splicing, via spliceosome; protein secretion; Golgi organization.
   
 0.988
Prp19
Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation.
   
 0.968
BCAS2
LD24242p; BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling.
   
 0.960
l(1)10Bb
L(1)10Bb protein; It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 
 0.897
Bx42
Bx42 (Bx42) encodes a nuclear protein that acts as a cofactor in Notch signalling pathway.
   
 
 0.896
fand
Pre-mRNA-splicing factor syf1 homolog; Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome. The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation. Essential for efficient pre-mRNA splicing. In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development. Part of it [...]
   
 
 0.895
ich
Ichor; Transcriptional activator. In tracheal terminal cells, regulates the transcription of factors involved in the formation of a mature apical extracellular matrix (aECM) which is essential for the integrity and shape of seamless tubes.
    
 
 0.884
Sf3a2
Splicing factor 3a subunit 2; RNA binding; zinc ion binding. It is involved in the biological process described with: positive regulation of gene expression; spliceosomal complex assembly; mRNA splicing, via spliceosome.
   
   0.857
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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