STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AP-1muAdaptor Protein complex 1, mu subunit (AP-1mu) encodes a clathrin adaptor involved in intracellular transport. It controls the trafficking of proteins, including the products of N and spdo. (426 aa)    
Predicted Functional Partners:
AP-1gamma
Adaptor Protein complex 1, gamma subunit (AP-1gamma) encodes a clathrin adaptor involved in vesicle trafficking.
   
 0.999
AP-1-2beta
Adaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation.
   
 0.999
AP-1sigma
AP complex subunit sigma; Clathrin adaptor activity; clathrin binding; Belongs to the adaptor complexes small subunit family.
   
 0.999
vers
Versatile (vers) encodes a component of the heterochromatin protein 1 complex that regulates adult testis germline stem cell fate.
   
   0.994
Odj
LD33778p; DNA binding; zinc ion binding. It is involved in the biological process described with: heterochromatin organization involved in chromatin silencing.
   
   0.994
AP-2alpha
AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter.
   
 0.968
AP-2sigma
Adaptor Protein complex 2, sigma subunit (AP-2sigma) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization.
   
 0.961
or
Adaptor protein complex AP-3 small chain sigma3; Orange (or) encodes an AP-3 adaptor complex component involved in ommochrome biosynthesis.
   
 0.944
Chc
Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles.
   
 0.923
Clc
Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
   
 0.915
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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