STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MpiZinc ion binding; mannose-6-phosphate isomerase activity. It is involved in the biological process described with: GDP-mannose biosynthetic process; carbohydrate metabolic process. (396 aa)    
Predicted Functional Partners:
Pgi
Phosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis.
  
 
 0.989
Pmm2
Probable phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.
  
 
 0.972
Pfk
ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
 
 0.963
Oscillin
Identical protein binding; glucosamine-6-phosphate deaminase activity.
   
 
 0.950
Gfat2
Glutamine:fructose-6-phosphate aminotransferase 2; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; protein N-linked glycosylation.
  
 
 0.942
Gfat1
Glutamine:fructose-6-phosphate aminotransferase 1, isoform A; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: carbohydrate derivative biosynthetic process.
  
 
 0.940
fbp
Fructose-1,6-bisphosphatase, isoform F; Fructose 1,6-bisphosphate 1-phosphatase activity. It is involved in the biological process described with: gluconeogenesis; fructose 6-phosphate metabolic process; fructose metabolic process; fructose 1,6-bisphosphate metabolic process; sucrose biosynthetic process; Belongs to the FBPase class 1 family.
   
 
 0.931
Hex-C
Phosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis.
  
 
 0.929
Hex-A
Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis.
    
 0.928
Hex-t1
Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate.
    
 0.928
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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