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MtnA protein (fruit fly) - STRING interaction network
"MtnA" - Metallothionein-1 in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MtnAMetallothionein-1; Metallothionein A is a member of the Metallothioneins family whose transcript level is higher than that of the other four Drosophila metallothioneins. Transcription is strongly induced by copper and cadmium ions and this induction depends on the transcription factor MTF-1; Belongs to the metallothionein superfamily. Type 5 family (40 aa)    
Predicted Functional Partners:
MTF-1
Metal response element-binding Transcription Factor-1 is a zinc finger protein that primarily controls the homeostasis of physiological trace metals, such as zinc and copper, and the detoxification of nonessential, toxic heavy metals, such as cadmium, mercury, and silver. It activates a number of genes in response to heavy metal load but also induces transcription of the copper importer Ctr1B upon copper depletion. Variations in the DNA binding site can affect its response to a specific metal (1006 aa)
       
 
  0.913
Ctr1B
Copper transporter 1B ensures copper uptake in the intestine. The transcription of the gene is upregulated under conditions of copper depletion via the metal-responsive transcription factor MTF-1 (174 aa)
       
 
  0.872
Cdlc2
Dynein light chain 2, cytoplasmic; Acts as a non-catalytic accessory component of a dynein complex (89 aa)
           
  0.750
Sod
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family (167 aa)
       
 
  0.693
Atox1
Antioxidant 1 copper chaperone null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1-/- larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body (71 aa)
           
  0.667
ATP7
ATP7, isoform B; Copper-exporting ATPase activity; copper ion transmembrane transporter activity; nucleotide binding; copper ion binding. It is involved in the biological process described with- copper ion transport; larval development; developmental pigmentation; adult chitin-containing cuticle pigmentation; metal ion homeostasis; cellular copper ion homeostasis (1254 aa)
           
  0.665
ZnT63C
Zinc transporter 63C, isoform F; Zinc transporter 63C (ZnT63C) is a plasma membrane resident zinc transporter belonging to the zinc transporter family that is mainly responsible for zinc export from the cell or into organelles. ZnT63C plays a key role in effluxing zinc from enterocytes into circulation during dietary zinc absorption (449 aa)
     
   
  0.659
MtnE
Metallothionein B (MtnE) is one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. MtnE shows the least specificity towards binding metal ions (41 aa)
           
  0.658
Tspo
Translocator protein is localized in the outer mitochondrial membrane and is thought to be involved in various pathways, including steroid and heme biosynthesis, apoptosis, protein import, cell proliferation and differentiation and also has been proposed to participate in the formation of the mitochondrial permeability transition pore (185 aa)
     
        0.606
Cat
Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide (506 aa)
     
   
  0.585
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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