STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tpc1Thiamine pyrophosphate carrier protein 1 (Tpc1) encodes an important protein for mitochondrial metabolism located at the inner mitochondrial membrane. Its main role is to import thiamine pyrophosphate (ThPP) into mitochondria. ThPP is an essential coenzyme for the E1 components of pyruvate dehydrogenase and oxoglutarate dehydrogenase, which are located in the mitochondrial matrix. (332 aa)    
Predicted Functional Partners:
RpL18
60S ribosomal protein L18; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation.
 
 
  
 0.880
CG2812
WD_REPEATS_REGION domain-containing protein.
    
 
 0.806
RpL14
Ribosomal protein L14 (RpL14) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL14 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles.
   
 
 0.678
RpS16
40S ribosomal protein S16; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cytoplasmic translation; translation; Belongs to the universal ribosomal protein uS9 family.
   
 
 0.659
CG14855
MFS domain-containing protein; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
      
 0.652
CG14856
FI01439p; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
      
 0.652
RpL27
60S ribosomal protein L27; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL27 family.
   
 
 0.636
RpL28
60S ribosomal protein L28; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL28 family.
   
   0.552
RpL6
Ribosomal protein L6, isoform B; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit assembly.
   
 
 0.551
RpL13
Ribosomal protein L13 (RpL13) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL13 family.
   
   0.550
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.