STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Not10CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity). (635 aa)    
Predicted Functional Partners:
Not11
CCR4-NOT transcription complex subunit 11, isoform A; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process.
    
 0.999
Rcd-1
Required for cell differentiation 1, isoform A; It is involved in the biological process described with: negative regulation of translation; mRNA catabolic process.
    
 0.999
Rga
Regulator of gene activity; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Essential for viability. Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes.
   
 0.999
Not3
CCR4-NOT transcription complex subunit 3 (Not3) encodes a poly(A)-specific ribonuclease involved in translation inhibition.
   
 0.999
Not1
Not1, isoform H; Not1 (Not1) encodes a poly(A)-specific ribonuclease involved in translation inhibition and ovarian follicle cell development.
    
 0.999
Pop2
Pop2, isoform E; Pop2 (Pop2) encodes a poly(A)-specific ribonuclease involved in translation inhibition.
    
 0.996
Cnot4
CCR4-NOT transcription complex subunit 4 (Cnot4) encodes a positive regulator of the Jak/Stat pathway which acts by stabilizing the DNA binding of the product of Stat92E.
     
 0.962
twin
Twin, isoform C; Twin (twin) encodes the CCR4 deadenylase, one of two enzymes in the CCR4-NOT complex that degrade mRNA poly(A) tails. It is required during oogenesis in germline stem cell self-renewal, synchronous germ cell division and prevention of cell death, as well as in early embryonic patterning through the deadenylation of specific maternal mRNAs.
   
 0.953
CG15262
FI22161p1; poly(A)-specific ribonuclease activity. It is involved in the biological process described with: negative regulation of translation; regulation of transcription, DNA-templated; nuclear-transcribed mRNA poly(A) tail shortening; regulation of stem cell population maintenance.
   
 0.872
CG31300
FI01822p.
      
 0.797
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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