STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hsc70-2Heat shock protein cognate 2 (Hsc70-2) encodes a member of the heat shock protein 70 family. It functions as chaperone protein in facilitating the proper folding of proteins. (633 aa)    
Predicted Functional Partners:
Hsp83
Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...]
 
 0.920
CG30156
AT29763p; Hsp70 protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding; cellular response to misfolded protein; ubiquitin-dependent ERAD pathway.
  
 
 0.907
Roe1
GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
  
 
 0.893
CG7794
AT04270p; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
   
 
 0.888
CG10164
IP12902p.
   
    0.873
CG31287
Uncharacterized protein, isoform A.
   
  
 0.873
Droj2
DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.
  
 0.870
CG14183
GH08353p; ATP binding.
  
 
 0.862
CG32591
FI08446p.
   
  
 0.860
CG13032
FI23334p1; It is involved in the biological process described with: non-motile cilium assembly; cytoplasmic microtubule organization.
  
   0.857
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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