STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCHa2Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides. (136 aa)    
Predicted Functional Partners:
CCHa2-R
Neuropeptide CCHamide-2 receptor; Receptor for the neuropeptide CCHamide-2. Belongs to the G-protein coupled receptor 1 family.
      
 0.896
CCHa1
Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R.
      
 0.838
Gbp1
Growth-blocking peptide 1 (Gbp1) encodes a cytokine that regulates the humoral immune response.
   
  
 0.706
Gbp2
Growth-blocking peptide 2, isoform A; N-acetyltransferase activity; cytokine activity. It is involved in the biological process described with: signal transduction.
   
  
 0.677
AstC
Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease.
   
  
 0.676
Ilp5
Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family.
   
  
 0.675
NPF
Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...]
      
 0.668
Ilp3
Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females.
   
  
 0.666
Lst
Limostatin, isoform B; Limostatin (Lst) encodes a peptide hormone produced by endocrine corpora cardiaca cells during starvation. It suppresses insulin production and secretion from insulin-producing cells by signaling through the G-protein coupled receptor encoded by PK1-R.
   
  
 0.663
upd2
Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes.
      
 0.662
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (42%) [HD]