STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG8483LD39025p; CG8483 encodes a predicted secreted protein with a SCP/V5/TPX domain found in venom proteins. CG8483 overexpression causes variable levels of lethality suggesting excess protein may have toxic effects; Belongs to the CRISP family. (392 aa)    
Predicted Functional Partners:
Rpt4
Regulatory particle triple-A ATPase 4 (Rpt4) encodes the 19S proteasomal ATPase, which is a component of the 26S proteosome complex. It localizes to the nucleolus and participates in regulating rRNA transcription. It physically interacts with the tumor suppressor encoded by BHD.
      
 0.605
rut
Ca(2+)/calmodulin-responsive adenylate cyclase; Rutabaga (rut) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity.
      
 0.533
CG16995
FI16842p1; It is involved in the biological process described with: multicellular organism reproduction; Belongs to the CRISP family.
  
   
 0.513
CG34049
IP19912p; Belongs to the CRISP family.
  
   
 0.504
Cht5
Chitinase 5 (Cht5) encodes an enzyme involved in the formation of chitin-based extracellular matrix at barrier tissues; Belongs to the glycosyl hydrolase 18 family.
   
    0.491
CG31482
SCP domain-containing protein.
  
   
 0.469
klhl10
Kelch like family member 10 (klhl10) encodes a protein that functions in spermatogenesis. It recruits substrates for a testis specific Cullin-3-based E3 ubiquitin ligase complex, which is required for caspase activation during the non-apoptotic process of spermatid terminal differentiation.
   
  
 0.423
CG43775
SCP domain-containing protein; It is involved in the biological process described with: multicellular organism reproduction.
      
0.410
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.