STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
emsHomeotic protein empty spiracles; Acts as a homeotic selector gene controlling antennal and mandibular segment identity; Belongs to the EMX homeobox family (494 aa)    
Predicted Functional Partners:
Transcription factor btd; Required for the development of the antennal, intercalary and mandibular segments of the head
Protein tailless; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and acti [...]
Fork head domain transcription factor slp1; Transcription factor involved in segmentation. Required for the formation of the mandibular lobe. Different levels of slp activity seem to be required in different segments
Inhibitory POU protein; Modulates gene transcription; simultaneously generates both a specific activator and an inhibitor of gene transcription, capable of modulating two distinct regulatory programs during neural development. Has a role in olfactory behavior; Belongs to the POU transcription factor family. Class- 4 subfamily
Huckebein is expressed in patches within the embryonic neuroectoderm and a subset of neuroblasts and their progeny, where it is required for proper neuronal specification and axon targeting. It is a terminal gap gene mediating the maternal terminal information at the posterior end of the blastoderm embryo
Sloppy paired 2 (Slp2) is a transcription factor of the fork-head family. Together with slp1, Slp2 regulates a wide variety of developmental processes including embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons
LIM homeobox 1, isoform A; Sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; zinc ion binding. It is involved in the biological process described with: negative regulation of transcription, DNA-templated; leg disc proximal/distal pattern formation; imaginal disc-derived leg morphogenesis; regulation of gene expression; positive regulation of transcription, DNA-templated; compound eye development; regulation of transcription, DNA-templated
Optix is a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor gro. It is involved in eye formation and morphogenetic furrow movement
Groucho (Gro) is a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. Groucho functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of Gro in response to MAPK activation weakens its repressor capacity
Zygotic gap protein knirps; Transcriptional repressor. Binds to multiple sites in the eve stripe 3 enhancer element. Plays an essential role in the segmentation process both by refining the expression patterns of gap genes and by establishing pair-rules stripes of gene expression
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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