node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG14207 | Droj2 | FBpp0074503 | FBpp0082220 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. | 0.706 |
CG14207 | Hsc70-4 | FBpp0074503 | FBpp0082516 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | 0.919 |
CG14207 | Hsc70Cb | FBpp0074503 | FBpp0292999 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.986 |
CG14207 | Hsp83 | FBpp0074503 | FBpp0305095 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.640 |
CG14207 | stv | FBpp0074503 | FBpp0112337 | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | Starvin, isoform E; Starvin (stv) encodes a BAG family member that binds heat shock proteins. It plays roles in somatic muscles and is involved in the chaperone pathway essential for muscle maintenance. It also acts as co-chaperone of Hsp70 proteins during recovery from stress, including cold stress. | 0.556 |
Cdc5 | Csp | FBpp0072468 | FBpp0311238 | Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | 0.979 |
Cdc5 | Hsc70-4 | FBpp0072468 | FBpp0082516 | Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | 0.829 |
Csp | Cdc5 | FBpp0311238 | FBpp0072468 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Cell division cycle 5, isoform A; DNA binding; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. | 0.979 |
Csp | Droj2 | FBpp0311238 | FBpp0082220 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. | 0.558 |
Csp | Hsc70-4 | FBpp0311238 | FBpp0082516 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | 0.972 |
Csp | Hsc70Cb | FBpp0311238 | FBpp0292999 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.868 |
Csp | Hsp83 | FBpp0311238 | FBpp0305095 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.620 |
Csp | Roe1 | FBpp0311238 | FBpp0086795 | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.645 |
DnaJ-1 | Droj2 | FBpp0076830 | FBpp0082220 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. | 0.746 |
DnaJ-1 | Hsc70-4 | FBpp0076830 | FBpp0082516 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. | 0.851 |
DnaJ-1 | Hsc70Cb | FBpp0076830 | FBpp0292999 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.934 |
DnaJ-1 | Hsp83 | FBpp0076830 | FBpp0305095 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.938 |
DnaJ-1 | Roe1 | FBpp0076830 | FBpp0086795 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.630 |
DnaJ-1 | Stip1 | FBpp0076830 | FBpp0077790 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. | Stress induced phosphoprotein 1; Hsp90 protein binding. | 0.771 |
Droj2 | CG14207 | FBpp0082220 | FBpp0074503 | DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. | RE23625p; Unfolded protein binding. It is involved in the biological process described with: protein refolding; chaperone-mediated protein folding; Belongs to the small heat shock protein (HSP20) family. | 0.706 |