STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
Coexpression
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Textmining
[Homology]
Score
Spn88EaSerine protease inhibitor 88Ea; Serine protease inhibitor with activity toward trypsin. Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin. Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade. Essential for unfolding and expansion of the wings after emergence from the pupal case. May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz. (427 aa)    
Predicted Functional Partners:
Spn43Ad
Serpin 43Ad; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; Belongs to the serpin family.
  
  
 0.777
Spn28Dc
Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...]
  
 
0.693
Spn27A
Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...]
  
 
0.673
Spn42Da
Serpin 42Da, isoform B; Serpin 42Da (Spn42Da) encodes an endopeptidase inhibitor involved in hormone processing regulation; Belongs to the serpin family.
  
0.671
Spn77Ba
Serine protease inhibitor 77Ba; Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection. Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade ; Belongs to the serpin family.
  
 
0.664
Spn77Bb
Serpin 77Bb; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
  
  
0.616
nec
GH10112p; Necrotic (nec) encodes a hemolymphatic Serpin that negatively regulates a serine protease involved in the immune activation of the Toll pathway. It is thought to function at the level or upstream of the serine protease encoded by psh.
  
  
0.616
Spn28Db
Serpin 28Db; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
  
  
0.610
Bem46
Palmitoyl-(protein) hydrolase activity.
      
 0.602
Spn77Bc
Serpin 77Bc (Spn77Bc) encodes a protein produced by the male accessory glands and transferred to females during mating.
  
  
0.596
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.