STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sap47Synapse-associated protein 47kD (Sap47) encodes a conserved protein associated with synaptic vesicles. It is required for intact synaptic and behavioural plasticity. (551 aa)    
Predicted Functional Partners:
Cbp53E
Calbindin-32; Calbindin 53E (Cbp53E) encodes a 6 EF-hand domain-containing protein that regulates neuronal development.
   
  
 0.622
vlc
Vulcan, isoform A; Vulcan (vlc) is induced above a basal level by 20-hydroxyecdysone in late third instar larvae. Its mutants die primarily as pharate adults with defects in ecdysone-induced leg morphogenesis.
      
 0.603
Csp
DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively.
      
 0.602
Mitofilin
MICOS complex subunit Mic60; Mitofilin (Mitofilin) encodes a major component of the mitochondrial contact site (MICOS) complex, which is located at the mitochondrial crista junctions. It maintains crista structure and contact sites, and regulates mitochondrial motility. Mitofilin product functions downstream of the kinase encoded by Pink1, to maintain mitochondrial structure and cellular homeostasis.
    
 
 0.536
Atpalpha
Sodium/potassium-transporting ATPase subunit alpha; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
   
 
 0.530
Syn
Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction.
   
  
 0.519
Bdbt
Bride of doubletime (Bdbt) encodes a protein that binds to a nuclear localization signal in the product of dco and is necessary for normal circadian dco activity on the product of per. The product of Bdbt also accumulates in cytosolic foci in photoreceptors during the middle of the night.
      
 0.507
alpha-Man-Ia
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
      
 0.495
Tsp42Ej
Tetraspanin 42Ej (Tsp42Ej) encodes a lysosomal member protein required for the degradation of endocytosed rhodopsin. It prevents light-induced retinal degeneration.
   
  
 0.473
CG32683
FI20035p1; G protein-coupled receptor binding. It is involved in the biological process described with: G protein-coupled receptor internalization.
   
  
 0.471
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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